ArticlePloS one2009
Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Mitochondrial genome study in blood of maternally inherited ALS cases.Human genomics · 2023Article
- Recent Advances, Systemic Therapy, and Molecular Targets in Adenoid Cystic Carcinoma of the Head and Neck.Journal of clinical medicine · 2023Review
- Biocomplexity and Fractality in the Search of Biomarkers of Aging and Pathology: Mitochondrial DNA Profiling of Parkinson's Disease.International journal of molecular sciences · 2020Article
- Different correlations between tumor size and cancer-related gene profiles according to histologic type of salivary gland tumor.International journal of clinical and experimental pathology · 2019Article
- MtDNA As a Cancer Marker: A Finally Closed Chapter?Current genomics · 2017Review
- Genetic alterations in salivary gland cancers.Cancer · 2016Review
- Mitochondrial A12308G alteration in tRNA(Leu(CUN)) in colorectal cancer samples.Diagnostic pathology · 2015Article
- Molecular biology of adenoid cystic carcinoma.Head & neck · 2012Review
- Mitochondrial genome variations in advanced stage endometriosis: a study in South Indian population.PloS one · 2012Article
- Large scale mtDNA sequencing reveals sequence and functional conservation as major determinants of homoplasmic mtDNA variant distribution.Mitochondrion · 2011Article
- Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.Oral oncology · 2011Article
- Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data.BMC cancer · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. METHODOLOGY: The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors. PRINCIPAL
findingsSeventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex. CONCLUSIONS/SIGNIFICANCE: Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.