ArticlePLoS genetics2009
Epigenetic control of virulence gene expression in Pseudomonas aeruginosa by a LysR-type transcription regulator.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.Cell host & microbe · 2025Article
- Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.bioRxiv : the preprint server for biology · 2025Article
- Comparative genomics reveals distinct diversification patterns among LysR-type transcriptional regulators in the ESKAPE pathogenMicrobial genomics · 2024Article
- Article
- Robust ParB Binding to Half-International journal of molecular sciences · 2023Article
- A Novel XRE-Type Regulator Mediates Phage Lytic Development and Multiple Host Metabolic Processes in Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
- Genome-Wide Analysis of Gene Expression Noise Brought About by Transcriptional Regulation inmSystems · 2022Article
- Stochastic activation of a family of TetR type transcriptional regulators controls phenotypic heterogeneity inPNAS nexus · 2022Article
- The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen.Molecular ecology · 2022Article
- Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs.Molecular microbiology · 2022Article
- Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation.Limnology and oceanography · 2021Article
- The LysR-Type Transcriptional Regulator BsrA (PA2121) Controls Vital Metabolic Pathways inmSystems · 2021Article
- Generation of Genetic Tools for Gauging Multiple-Gene Expression at the Single-Cell Level.Applied and environmental microbiology · 2021Article
- Control of a programmed cell death pathway in Pseudomonas aeruginosa by an antiterminator.Nature communications · 2021Article
- Waddington's Landscapes in the Bacterial World.Frontiers in microbiology · 2021Review
- Pseudomonas aeruginosa ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of Macrophages.Infection and immunity · 2019Article
- Parallel evolution leading to impaired biofilm formation in invasive Salmonella strains.PLoS genetics · 2019Article
- A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii.Nature microbiology · 2018Article
- A comprehensive multi-omics approach uncovers adaptations for growth and survival of Pseudomonas aeruginosa on n-alkanes.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Phenotypic variation within an isogenic bacterial population is thought to ensure the survival of a subset of cells in adverse conditions. The opportunistic pathogen Pseudomonas aeruginosa variably expresses several phenotypes, including antibiotic resistance, biofilm formation, and the production of CupA fimbriae. Here we describe a previously unidentified bistable switch in P. aeruginosa. This switch controls the expression of a diverse set of genes, including aprA, which encodes the secreted virulence factor alkaline protease. We present evidence that bistable expression of PA2432, herein named bexR (bistable expression regulator), which encodes a LysR-type transcription regulator, controls this switch. In particular, using DNA microarrays, quantitative RT-PCR analysis, chromatin immunoprecipitation, and reporter gene fusions, we identify genes directly under the control of BexR and show that these genes are bistably expressed. Furthermore, we show that bexR is itself bistably expressed and positively autoregulated. Finally, using single-cell analyses of a GFP reporter fusion, we present evidence that positive autoregulation of bexR is necessary for bistable expression of the BexR regulon. Our findings suggest that a positive feedback loop involving a LysR-type transcription regulator serves as the basis for an epigenetic switch that controls virulence gene expression in P. aeruginosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.