Evidence map›Paper›PMID 20040909›Full record

ReviewClinical advances in hematology & oncology : H&O2009

Waldenstrom's macroglobulinemia: Recent advances in biology and therapy.

Natalia Neparidze, Madhav V Dhodapkar

Open access · greenAbstract readReview
In one paragraph

Review in Clinical advances in hematology & oncology : H&O, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Natalia NeparidzeYale University, New Haven, CT 06510, USA.
Madhav V Dhodapkar
Yale University · US

Funding

Anti-Tumor immunity in myelomaR01CA106802 · NCI · YALE UNIVERSITY · PI DHODAPKAR, MADHAV V · 2004 to 2016
$3.3M
NCI NIH HHS R01 CA106802
6 · The paper itself

Abstract

Waldenstrom's macroglobulinemia (WM) is a B-cell disorder characterized by bone marrow infiltration with clonal lymphoplasmacytic cells (LPCs), along with an immunoglobulin M monoclonal gammopathy. Recent studies have led to several insights into disease biology as well as the development of an international staging system. Patients with asymptomatic macroglobulinemia should be observed without therapy. Options for frontline therapy include alkylating agents, nucleoside analogs, and rituximab, either as monotherapy or in combination. Although objective responses are common, complete remissions are infrequent. Several novel agents including proteasome inhibitors and thalidomide, as well as high-dose chemotherapy and stem cell transplantation are being incorporated into the therapeutic armamentarium in WM and show promising activity. This report provides an update on recent advances in biology and treatment of this disease.

Indexed as

HumansWaldenstrom Macroglobulinemia

Identifiers

PMID20040909
PMCPMC3612541
OpenAlexW166958795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.