ArticleDiabetes care2010
Altered C-fiber function as an indicator of early peripheral neuropathy in individuals with impaired glucose tolerance.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02549534 (Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer), which is not on this map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Who cites it
42 citing papers in PubMed, 88 citations in OpenAlex.
- Trial
- Article
- Indole metabolism and its role in diabetic macrovascular and microvascular complications.American heart journal plus : cardiology research and practice · 2025Review
- Role of microglia in diabetic neuropathic pain.Frontiers in cell and developmental biology · 2024Review
- Alleviative Effect ofPlants (Basel, Switzerland) · 2023Article
- The foot in diabetes - a reminder of an ever-present risk.Clinical medicine (London, England) · 2023Review
- Application of SygenBioengineering (Basel, Switzerland) · 2022Review
- Small Fiber Neuropathy in Diabetes Polyneuropathy: Is It Time to Change?Journal of diabetes science and technology · 2022Review
- New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review.Frontiers in endocrinology · 2022Review
- Diabetic neuropathy: an insight on the transition from synthetic drugs to herbal therapies.Journal of diabetes and metabolic disorders · 2021Review
- Cutaneous innervation in impaired diabetic wound healing.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres.Diagnostics (Basel, Switzerland) · 2021Review
- The Role of Cutaneous Microcirculatory Responses in Tissue Injury, Inflammation and Repair at the Foot in Diabetes.Frontiers in bioengineering and biotechnology · 2021Review
- Is there cardiac autonomic neuropathy in prediabetes?Autonomic neuroscience : basic & clinical · 2020Review
- Clinical and Structural Outcomes After Rotator Cuff Repair in Patients With Diabetes: A Meta-analysis.Orthopaedic journal of sports medicine · 2020Review
- A Synoptic Overview of Neurovascular Interactions in the Foot.Frontiers in endocrinology · 2020Review
- Article
- The Association Between Phosphorylated Neurofilament Heavy Chain (pNF-H) and Small Fiber Neuropathy (SFN) in Patients with Impaired Glucose Tolerance.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
- Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019 · on this mapReview
- Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population.Journal of diabetes investigation · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study explored the importance of glycemic burden compared with features of the metabolic syndrome in the pathogenesis of diabetic neuropathy by comparing C-fiber function in people with type 1 diabetes to that in people with impaired glucose tolerance (IGT). RESEARCH DESIGN AND
methodsThe axon reflex-elicited flare areas (LDIflares) were measured with a laser Doppler imager (LDI) in age-, height-, and BMI-matched groups with IGT (n = 14) and type 1 diabetes (n = 16) and in healthy control subjects (n = 16).
resultsThe flare area was reduced in the IGT group compared with the control (2.78 +/- 1.1 vs. 5.23 +/- 1.7 cm(2), P = 0.0001) and type 1 diabetic (5.16 +/- 2.3 cm(2), P = 0.002) groups, whereas the flare area was similar in the type 1 diabetic and control groups.
conclusionsThis technique suggests that small-fiber neuropathy is a feature of IGT. The absence of similar small-fiber neuropathy in those with longstanding type 1 diabetes suggests that glycemia may not be the major determinant of small-fiber neuropathy in IGT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.