ArticleThe Plant cell2009
Arabidopsis Tic62 and ferredoxin-NADP(H) oxidoreductase form light-regulated complexes that are integrated into the chloroplast redox poise.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 116 citations in OpenAlex.
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- EPR studies of ferredoxin in spinach and cyanobacterial thylakoids related to photosystem I-driven NADPPhotosynthesis research · 2024Article
- Chloroplast ATP synthase: From structure to engineering.The Plant cell · 2024Review
- TurboID reveals the proxiomes of Chlamydomonas proteins involved in thylakoid biogenesis and stress response.Plant physiology · 2023Article
- Loss of Chloroplast GNAT Acetyltransferases Results in Distinct Metabolic Phenotypes in Arabidopsis.Plant & cell physiology · 2023Article
- Development of Two-Dimensional Model of Photosynthesis in Plant Leaves and Analysis of Induction of Spatial Heterogeneity of COPlants (Basel, Switzerland) · 2022Article
- Deciphering the Molecular Mechanisms of Chilling Tolerance inInternational journal of molecular sciences · 2022Article
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- Arabidopsis fibrillin 1-2 subfamily members exert their functions via specific protein-protein interactions.Journal of experimental botany · 2022Article
- Isothermal titration calorimetry of membrane protein interactions: FNR and the cytochrome bBiophysical journal · 2022Article
- Two plastid POLLUX ion channel-like proteins are required for stress-triggered stromal Ca2+release.Plant physiology · 2021Article
- Change in HPlants (Basel, Switzerland) · 2021Article
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- Catalytic Reactions and Energy Conservation in the CytochromeChemical reviews · 2021Review
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- Developmental acclimation of the thylakoid proteome to light intensity in Arabidopsis.The Plant journal : for cell and molecular biology · 2021Article
- Inactivation of HPlants (Basel, Switzerland) · 2020Article
- Exogenous Abscisic Acid Can Influence Photosynthetic Processes in Peas through a Decrease in Activity of HBiology · 2020Article
- Tweaking Photosynthesis: FNR-TROL Interaction as Potential Target for Crop Fortification.Frontiers in plant science · 2020Article
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12 authors at 7 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Translocation of nuclear-encoded preproteins across the inner envelope of chloroplasts is catalyzed by the Tic translocon, consisting of Tic110, Tic40, Tic62, Tic55, Tic32, Tic20, and Tic22. Tic62 was proposed to act as a redox sensor of the complex because of its redox-dependent shuttling between envelope and stroma and its specific interaction with the photosynthetic protein ferredoxin-NADP(H) oxidoreductase (FNR). However, the nature of this close relationship so far remained enigmatic. A putative additional localization of Tic62 at the thylakoids mandated further studies examining how this feature might be involved in the respective redox sensing pathway and the interaction with its partner protein. Therefore, both the association with FNR and the physiological role of the third, thylakoid-bound pool of Tic62 were investigated in detail. Coexpression analysis indicates that Tic62 has similar expression patterns as genes involved in photosynthetic functions and protein turnover. At the thylakoids, Tic62 and FNR form high molecular weight complexes that are not involved in photosynthetic electron transfer but are dynamically regulated by light signals and the stromal pH. Structural analyses reveal that Tic62 binds to FNR in a novel binding mode for flavoproteins, with a major contribution from hydrophobic interactions. Moreover, in absence of Tic62, membrane binding and stability of FNR are drastically reduced. We conclude that Tic62 represents a major FNR interaction partner not only at the envelope and in the stroma, but also at the thylakoids of Arabidopsis thaliana and perhaps all flowering plants. Association with Tic62 stabilizes FNR and is involved in its dynamic and light-dependent membrane tethering.
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