ArticleDevelopment (Cambridge, England)2010
Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 128 citations in OpenAlex.
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- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
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- A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development.PLoS biology · 2023Article
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
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- Single-cell transcriptome profiles ofeLife · 2023Article
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- Interspecific variation in sex-specific gustatory organs in Drosophila.The Journal of comparative neurology · 2022Article
- Sexually dimorphic peripheral sensory neurons regulate copulation duration and persistence in male Drosophila.Scientific reports · 2022Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
- Sex determination geneeLife · 2021Article
- Generation and characterization ofJournal of neurogenetics · 2021Article
- The Slit-binding Ig1 domain is required for multiple axon guidance activities of Drosophila Robo2.Genesis (New York, N.Y. : 2000) · 2021Article
- Male courtship song drives escape responses that are suppressed for successful mating.Scientific reports · 2021Article
- Doublesex regulates fruitless expression to promote sexual dimorphism of the gonad stem cell niche.PLoS genetics · 2021Article
- Investigation ofeLife · 2021Article
- Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.PLoS genetics · 2021Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Although nervous system sexual dimorphisms are known in many species, relatively little is understood about the molecular mechanisms generating these dimorphisms. Recent findings in Drosophila provide the tools for dissecting how neurogenesis and neuronal differentiation are modulated by the Drosophila sex-determination regulatory genes to produce nervous system sexual dimorphisms. Here we report studies aimed at illuminating the basis of the sexual dimorphic axonal projection patterns of foreleg gustatory receptor neurons (GRNs): only in males do GRN axons project across the midline of the ventral nerve cord. We show that the sex determination genes fruitless (fru) and doublesex (dsx) both contribute to establishing this sexual dimorphism. Male-specific Fru (Fru(M)) acts in foreleg GRNs to promote midline crossing by their axons, whereas midline crossing is repressed in females by female-specific Dsx (Dsx(F)). In addition, midline crossing by these neurons might be promoted in males by male-specific Dsx (Dsx(M)). Finally, we (1) demonstrate that the roundabout (robo) paralogs also regulate midline crossing by these neurons, and (2) provide evidence that Fru(M) exerts its effect on midline crossing by directly or indirectly regulating Robo signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.