ArticleDevelopment (Cambridge, England)2010
Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Capicua regulates the survival of Cajal-Retzius cells in the postnatal hippocampus.Cell death & disease · 2025Article
- Neocortical neurogenesis: a proneural gene perspective.The FEBS journal · 2025Review
- Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development.Frontiers in cell and developmental biology · 2022Article
- Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons.Frontiers in cellular neuroscience · 2018Review
- Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Origin and Migration of Olfactory Cajal-Retzius Cells.Frontiers in neuroanatomy · 2017Article
- Rostro-Caudal and Caudo-Rostral Migrations in the Telencephalon: Going Forward or Backward?Frontiers in neuroscience · 2017Review
- Transcription factor ETV1 is essential for rapid conduction in the heart.The Journal of clinical investigation · 2016Article
- Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex.Frontiers in neuroscience · 2015Review
- Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.Cell reports · 2013Article
- Signaling in cell differentiation and morphogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem.Developmental biology · 2012Article
- Article
- FGFs: Neurodevelopment's Jack-of-all-Trades - How Do They Do it?Frontiers in neuroscience · 2011Article
- The germinal zones of the basal ganglia but not the septum generate GABAergic interneurons for the cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium.PLoS biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Cajal-Retzius (CR) cells play a key role in the formation of the cerebral cortex. These pioneer neurons are distributed throughout the cortical marginal zone in distinct graded distributions. Fate mapping and cell lineage tracing studies have recently shown that CR cells arise from restricted domains of the pallial ventricular zone, which are associated with signalling centres involved in the early regionalisation of the telencephalic vesicles. In this study, we identified a subpopulation of CR cells in the rostral telencephalon that expresses Er81, a downstream target of Fgf8 signalling. We investigated the role of the rostral telencephalic patterning centre, which secretes FGF molecules, in the specification of these cells. Using pharmacological inhibitors and genetic inactivation of Fgf8, we showed that production of Fgf8 by the rostral telencephalic signalling centre is required for the specification of the Er81+ CR cell population. Moreover, the analysis of Fgf8 gain-of-function in cultivated mouse embryos and of Emx2 and Gli3 mutant embryos revealed that ectopic Fgf8 signalling promotes the generation of CR cells with a rostral phenotype from the dorsal pallium. These data showed that Fgf8 signalling is both required and sufficient to induce rostral CR cells. Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.