ArticleBMC genomics2009
A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Association ofAnimals : an open access journal from MDPI · 2021Article
- Genome-Wide Epistatic Interaction Networks Affecting Feed Efficiency in Duroc and Landrace Pigs.Frontiers in genetics · 2020Article
- Use of haplotypes to identify regions harbouring lethal recessive variants in pigs.Genetics, selection, evolution : GSE · 2017Article
- Identification of Differentially Expressed Genes Associated with Litter Size in Berkshire Pig Placenta.PloS one · 2016Article
- Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency.Scientific reports · 2015Article
- Detecting inbreeding depression for reproductive traits in Iberian pigs using genome-wide data.Genetics, selection, evolution : GSE · 2015Article
- Article
- Bayesian analysis of additive epistasis arising from new mutations in mice.Genetics research · 2014Article
- Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross.BMC genomics · 2013Article
- Selection of internal control genes for real-time quantitative PCR in ovary and uterus of sows across pregnancy.PloS one · 2013Article
- Current applications of models of genetic effects with interactions across the genome.Current genomics · 2012Article
- Genes with expression levels correlating to drip loss prove association of their polymorphism with water holding capacity of pork.Molecular biology reports · 2012Article
- Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population.BMC genetics · 2011Article
- Progeny-testing of full-sibs IBD in a SSC2 QTL region highlights epistatic interactions for fatness traits in pigs.BMC genetics · 2011Article
- Partial short-read sequencing of a highly inbred Iberian pig and genomics inference thereof.Heredity · 2011Article
- Association of porcine heparanase and hyaluronidase 1 and 2 with reproductive and production traits in a landrace-duroc-yorkshire population.Frontiers in genetics · 2011Article
- Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc × Pietrain population.Genetics, selection, evolution : GSE · 2010Article
- Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line.Genetics, selection, evolution : GSE · 2010Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement of this trait through artificial selection. Moreover, the relative contributions of additive, dominant and epistatic QTL to the genetic variance of pig prolificacy remain to be defined. In this work, we have undertaken this issue by performing one-dimensional and bi-dimensional genome scans for number of piglets born alive (NBA) and total number of piglets born (TNB) in a three generation Iberian by Meishan F(2) intercross.
resultsThe one-dimensional genome scan for NBA and TNB revealed the existence of two genome-wide highly significant QTL located on SSC13 (P < 0.001) and SSC17 (P < 0.01) with effects on both traits. This relative paucity of significant results contrasted very strongly with the wide array of highly significant epistatic QTL that emerged in the bi-dimensional genome-wide scan analysis. As much as 18 epistatic QTL were found for NBA (four at P < 0.01 and five at P < 0.05) and TNB (three at P < 0.01 and six at P < 0.05), respectively. These epistatic QTL were distributed in multiple genomic regions, which covered 13 of the 18 pig autosomes, and they had small individual effects that ranged between 3 to 4% of the phenotypic variance. Different patterns of interactions (a x a, a x d, d x a and d x d) were found amongst the epistatic QTL pairs identified in the current work.
conclusionsThe complex inheritance of prolificacy traits in pigs has been evidenced by identifying multiple additive (SSC13 and SSC17), dominant and epistatic QTL in an Iberian x Meishan F(2) intercross. Our results demonstrate that a significant fraction of the phenotypic variance of swine prolificacy traits can be attributed to first-order gene-by-gene interactions emphasizing that the phenotypic effects of alleles might be strongly modulated by the genetic background where they segregate.
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