ArticleThe Journal of infectious diseases2010
Piglet models of acute or chronic Clostridium difficile illness.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
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- Protection against Clostridioides difficile disease by a naturally avirulent strain.Cell host & microbe · 2025Article
- Methods of a Reproducible Mouse Model of Clostridioides difficile Infection to Investigate Novel Bacterial-Based Therapies.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Porcine Monocyte DNA Traps Formed during Infection with PathogenicPathogens (Basel, Switzerland) · 2024Article
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- Detection of EnterotoxigenicLife (Basel, Switzerland) · 2023Article
- Gut Microbiota Composition Associated withPathogens (Basel, Switzerland) · 2022Review
- Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease.Gut pathogens · 2022Article
- Application of Microbiome Management in Therapy forPathogens (Basel, Switzerland) · 2021Review
- Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies.JCI insight · 2020Article
- Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium againstMicroorganisms · 2020Article
- Enterotoxic Clostridia:Microbiology spectrum · 2019Review
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- The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis.Human vaccines & immunotherapeutics · 2019Article
- Vaccines for enteric diseases.Human vaccines & immunotherapeutics · 2019Article
- An Engineered Synthetic Biologic Protects AgainstFrontiers in microbiology · 2018Article
- Diarrhoea in neonatal piglets: a case control study on microbiological findings.Porcine health management · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the piglet model of Clostridium difficile illness (CDI) in humans, because swine are naturally susceptible to C. difficile. The piglet is a reproducible model of acute or chronic CDI with characteristic pseudomembranous colitis. Germ-free piglets were consistently and extensively colonized after oral challenge with the human strain 027/BI/NAP1, establishing an infectious dose-age relationship. This allowed a demarcation between acute fatal and chronic models. The clinical manifestations of disease inclusive of gastrointestinal and systemic symptoms and characteristic mucosal lesions of the large bowel (including pseudomembranous colitis) are described. Additionally, we demonstrate the presence of toxins in feces, body fluids, and serum and a significant elevation in interleukin 8 levels in animals with severe disease. We conclude that piglets infected with C. difficile mimic many of the key characteristics observed in humans with CDI and are suitable animals in which to investigate the role played by virulence attributes, drug efficacy, and vaccine candidates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.