Evidence map›Paper›PMID 20039451›Full record

SynthesisWorld journal of gastroenterology2010

Systematic review of randomised controlled trials: probiotics for functional constipation.

Anna Chmielewska, Hania Szajewska

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01587846 (Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children - Randomized, Double Blind, Placebo Controlled Study), which is not on this map. Cited by 85 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 10 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01587846 phase3unknown statusnot on this mapstarted 2012, after this paper: background citation

Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children - Randomized, Double Blind, Placebo Controlled Study

TypeinterventionalSponsorSisters of Mercy University HospitalRan2012 to 2013Enrolled300ConditionsAbdominal Pain, Constipation - FunctionalArmsAdministration of L.reuteri in children with abdominal pain, Administration of placebo in children with abdominal pain, Administration of L.reuteri in children with constipation, Administration of placebo in children with constipation
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 10 syntheses or guidelines pooled it, 210 citations in OpenAlex.

  1. Pooled it
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  6. GUT MICROBIOTA AND THE USE OF PROBIOTICS IN CONSTIPATION IN CHILDREN AND ADOLESCENTS: SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020
    Pooled it
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  11. Trial
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  19. [Functional Constipation].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna ChmielewskaDepartment of Paediatrics, The Medical University of Warsaw, 01-184 Warsaw, Dzialdowska 1, Poland.
Hania Szajewska
Medical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo systematically evaluate and update evidence on the efficacy and safety of probiotic supplementation for the treatment of constipation.

methodsThe MEDLINE, EMBASE, CINAHL, and Cochrane Library databases were searched in May 2009 for randomised controlled trials (RCTs) performed in paediatric or adult populations related to the study aim.

resultsWe included five RCTs with a total of 377 subjects (194 in the experimental group and 183 in the control group). The participants were adults (three RCTs, n = 266) and children (two RCTs, n = 111) with constipation. In adults, data suggests a favourable effect of treatment with Bifidobacterium lactis DN-173 010, Lactobacillus casei Shirota, and Escherichia coli Nissle 1917 on defecation frequency and stool consistency. In children, L. casei rhamnosus Lcr35, but not L. rhamnosus GG, showed a beneficial effect.

conclusionUntil more data are available, we believe the use of probiotics for the treatment of constipation condition should be considered investigational.

Indexed as

Therapies, InvestigationalAdolescentAdultAgedChildChild, PreschoolConstipationEvidence-Based MedicineFemaleHumansMaleMiddle AgedProbioticsRandomized Controlled Trials as TopicTreatment OutcomeYoung Adult

Identifiers

PMID20039451
PMCPMC2799919
OpenAlexW2150381142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.