Evidence map›Paper›PMID 20039306›Full record

ArticleEuropean journal of immunology2010

Does TLR2 regulate intestinal inflammation?

Allan McI Mowat

Abstract readComment
PubMed Publisher
In one paragraph

Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Allan McI MowatDivision of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, UK. a.m.mowat@clinmed.gla.ac.uk
Centre for Inflammation Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is almost no aspect of the immune response that is not regulated by TLR. Initially described as drivers of the innate immune response to pathogens, it is now clear that the TLR family can also influence most aspects of adaptive immunity, as well as determine how tissue cells interact with microbes in their environment. In particular, the intestine and its immune system must co-exist with an enormous community of commensal bacteria and are also on constant alert against invading pathogens. Unsurprisingly, there is therefore great interest in how TLR might regulate physiological and pathological reactions in the gut. An article in this issue of the European Journal of Immunology addresses this question with some elegant experiments that indicate that TLR2 is not essential for the pathogenesis or T-cell-mediated regulation of different models of inflammatory bowel disease in mice.

Indexed as

Signal TransductionAcute DiseaseAnimalsChronic DiseaseForkhead Transcription FactorsHelicobacter hepaticusHelicobacter InfectionsHost-Pathogen InteractionsInflammatory Bowel DiseasesMiceMice, KnockoutT-Lymphocytes, RegulatoryToll-Like Receptor 2Forkhead Transcription FactorsFoxp3 protein, mouseTlr2 protein, mouseToll-Like Receptor 2

Identifiers

PMID20039306
OpenAlexW2112188071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.