Trial reportJournal of behavioral medicine2010
Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement.
Trial report in Journal of behavioral medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Stress and pain: modality-specific opioid mediation of stress-induced analgesia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Trial
- A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Do Resting Plasma β-Endorphin Levels Predict Responses to Opioid Analgesics?The Clinical journal of pain · 2017Trial
- Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.Journal of behavioral medicine · 2013Trial
- μ-Opioid Receptor-Mediated AT1R-TLR4 Crosstalk Promotes Microglial Activation to Modulate Blood Pressure Control in the Central Nervous System.Antioxidants (Basel, Switzerland) · 2021Article
- Anxiety, Depression, and Pain: Considerations in the Treatment of Patients with Uncontrolled Hypertension.Current hypertension reports · 2020Review
- Taking rejection to heart: Associations between blood pressure and sensitivity to social pain.Biological psychology · 2018Article
- Is Resolution of Chronic Pain Associated With Changes in Blood Pressure-related Hypoalgesia?Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- Chronic Pain: How Challenging Are DDIs in the Analgesic Treatment of Inpatients with Multiple Chronic Conditions?PloS one · 2017Article
- GPCR dimerization in brainstem nuclei contributes to the development of hypertension.British journal of pharmacology · 2015Article
- Article
- The relationship between blood pressure and pain.Journal of clinical hypertension (Greenwich, Conn.) · 2013Review
- The relationship between resting arterial blood pressure and acute postoperative pain in endodontic patients.Journal of orofacial pain · 2012Article
- Relationship between resting blood pressure and laboratory-induced pain among healthy children.Gender medicine · 2011Article
- The autonomic and nociceptive response to acute experimental stress is impaired in people with knee osteoarthritis: A preliminary study.Neurobiology of pain (Cambridge, Mass.)Article
- Hypertension and pain: A state-based framework for cardiovascular-nociceptive coupling.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
This study used a placebo-controlled, between-subjects opioid blockade design to evaluate endogenous opioid involvement in the hypoalgesia associated with elevated resting blood pressure (BP) in 163 healthy individuals. Participants were randomly assigned to Drug condition (placebo, naltrexone) and Task Order (computerized maze task with harassment followed by an ischemic pain task or vice versa). Resting BP was assessed, followed by drug administration, and then the pain and maze tasks. A significant Drug x Systolic BP (SBP) interaction was observed on McGill Pain Questionnaire-Affective pain ratings (P < .01), indicating that BP-related hypoalgesia observed under placebo was absent under opioid blockade. A significant Gender x Drug x SBP x Task Order interaction was observed for VAS pain intensity (P < .02). Examination of simple effects comprising this interaction suggested that BP-related hypoalgesia occurred only in male participants who experienced the pain task in the absence of emotional arousal, and indicated that this hypoalgesia occurred under placebo but not under opioid-blockade. Results suggest that under some circumstance, BP-related hypoalgesia may have an endogenous opioid-mediated component in healthy individuals, particularly men.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.