ArticleInternational urology and nephrology2010
The association of glomerular filtration rate and erectile dysfunction with severity of coronary artery disease in patients presenting with chest pain.
Article in International urology and nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Association between renal function, erectile function and coronary artery disease: detection with coronary angiography.Korean journal of urology · 2015Article
- Uric acid level and erectile dysfunction in patients with coronary artery disease.The journal of sexual medicine · 2014Article
- Glomerular filtration rate is related to severity of obstructive coronary artery disease in patients undergoing coronary angiography.International urology and nephrology · 2012Article
- Stage effect of chronic kidney disease in erectile function.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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6 authors at 1 institution in 1 country.
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Abstract
backgroundThe most common cause of death in patients with chronic kidney disease is cardiovascular. Coexistence of reduced estimated glomerular filtration rate (eGFR) and erectile dysfunction (ED) may predate severe underlying coronary artery disease (CAD). The aim of this study was to evaluate the predictive value of presence and severity of ED and reduced estimated eGFR in the risk stratification of CAD in patients with chest pain.
methodsTwo hundred and sixty-five consecutive male patients with chest pain were included. All patients underwent exercise stress test (EST), of whom those with positive EST underwent coronary angiography. eGFR was calculated and sexual health inventory for men (SHIM) form was applied to evaluate ED. The relation between SHIM scores, eGFR and the number of arteries with significant lesions was evaluated.
resultsOf the 265 male patients, 105 had positive EST while the remaining 160 patients had negative EST. ED was present in 62 patients (38.8%) in the EST (-) group and in 64 patients (61%) in the EST (+) group (P = 0.000). In the EST (+) group, coronary angiography (CAG) revealed normal coronary anatomy or insignificant coronary lesions in 19 (18%), one-vessel disease in 45 (43%), two-vessel disease in 22 (21%) and three-vessel disease in 19 (18%) patients, respectively. The lowest ED prevalence (36.8%) was seen in patients who had normal coronary anatomy or insignificant coronary lesions while the highest prevalence was in those with three-vessel disease (89.5%). When eGFR were taken into account, there was a significant difference between the groups as well (107.2 ± 19.2 ml/min in the EST (-) group versus 94.1 ± 20.0 ml/min in the EST (+) group; P = 0.001).
conclusionThe presence and severity of ED and reduced eGFR are associated with the severity of underlying CAD in patients presenting with chest pain, and they could be implemented in the risk stratification of these patients.
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