ArticleThe review of diabetic studies : RDS2009
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide.
Article in The review of diabetic studies : RDS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Correlation between Neutrophil-to-Lymphocyte Ratio and Cerebral Edema in Children with Severe Diabetic Ketoacidosis.Biomedicines · 2023Article
- Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats.Probiotics and antimicrobial proteins · 2023Article
- Article
- Neuroinflammatory responses in diabetic retinopathy.Journal of neuroinflammation · 2015Review
- Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats.Metabolic brain disease · 2014Article
- Tissue resident stem cells: till death do us part.Biogerontology · 2013Review
- Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy.CNS neuroscience & therapeutics · 2013Article
- Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation.Acta pharmacologica Sinica · 2013Article
- Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy.Progress in retinal and eye research · 2012Review
- Review
- C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells.Diabetologia · 2011Article
- Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats.The Malaysian journal of medical sciences : MJMS · 2011Article
- Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis.Brain research · 2011Article
- The beneficial effects of C-Peptide on diabetic polyneuropathy.The review of diabetic studies : RDS · 2009Article
- Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic encephalopathy is a recently recognized complication in type 1 diabetes. In this review, we summarize a series of experimental results obtained longitudinally in the spontaneously type 1 diabetic BB/Wor-rat, and bringing out the beneficial effects of C-peptide replacement. It is increasingly clear that lack of insulin and C-peptide, and perturbations of their signaling cascades in type 1 diabetes are detrimental to the regulation of neurotrophic factors and their receptors. Other consequences of such deficits and perturbations are innate inflammatory responses with effects on synaptogenesis, neurite degeneration, and early behavioral abnormalities. Replacement of C-peptide, which does not effect hyperglycemia, has beneficial effects on a variety of pro-apoptotic stressors, oxidative stressors, and finally on apoptosis. Eventually, this cascade of events leads to neuronal loss and decreased densities of white matter myelinating cells, with more profound deficits in behavioral and cognitive function. Such changes are likely to underlie gray and white matter atrophy in type 1 diabetes, and are significantly prevented by full C-peptide replacement. Present data demonstrate that C-peptide replacement has beneficial effects on numerous sequential and partly interrelated pathogenetic mechanisms, resulting in prevention of neuronal and oligodendroglial cell loss, with significant prevention of neurobehavioral and cognitive functions.
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Registered trials
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