ArticleMolecular psychiatry2011
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
Article in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 16 of them syntheses that pooled it.
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Who cites it
141 citing papers in PubMed, 16 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system.Molecular psychiatry · 2022Pooled it
- Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.Translational psychiatry · 2022Pooled it
- The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis.Genes & genomics · 2021Pooled it
- Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk.International journal of molecular sciences · 2019Pooled it
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.JAMA psychiatry · 2017Pooled it
- An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.Biological psychiatry · 2017Pooled it
- Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis.Scientific reports · 2016Pooled it
- Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Pooled it
- Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.Human molecular genetics · 2013Pooled it
- A genome-wide association study of depressive symptoms.Biological psychiatry · 2013Pooled it
- A mega-analysis of genome-wide association studies for major depressive disorder.Molecular psychiatry · 2013Pooled it
- Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Translational psychiatry · 2012Pooled it
- Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.Molecular psychiatry · 2012Pooled it
- Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research.Journal of child psychology and psychiatry, and allied disciplines · 2011Pooled it
- GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.Molecular psychiatry · 2011Pooled it
- Genome-wide association scan of trait depression.Biological psychiatry · 2010Pooled it
- Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance.European archives of psychiatry and clinical neuroscience · 2017Trial
- Maternal antenatal depression and offspring DNA methylation.Journal of affective disorders · 2026Article
- The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex.bioRxiv : the preprint server for biology · 2026Article
- TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.Science advances · 2026Article
81 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 12 institutions in 2 countries.
Funding
Abstract
We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and 1636 screened controls. No genome-wide evidence for association was detected. We also carried out a meta-analysis of three European-ancestry MDD GWAS data sets: STAR*D, Genetics of Recurrent Early-onset Depression and the publicly available Genetic Association Information Network-MDD data set. These data sets, totaling 3957 cases and 3428 controls, were genotyped using four different platforms (Affymetrix 6.0, 5.0 and 500 K, and Perlegen). For each of 2.4 million HapMap II single-nucleotide polymorphisms (SNPs), using genotyped data where available and imputed data otherwise, single-SNP association tests were carried out in each sample with correction for ancestry-informative principal components. The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10⁻⁷), SP4 (P=7.68 x 10⁻⁷) and GRM7 (P=1.11 x 10⁻⁶). Additional exploratory analyses were carried out for a narrower phenotype (recurrent MDD with onset before age 31, N=2191 cases), and separately for males and females. Several of the best findings were supported primarily by evidence from narrow cases or from either males or females. On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Larger samples will be required to determine whether any common SNPs are significantly associated with MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.