ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Batf stabilizes Th17 cell development via impaired Stat5 recruitment of Ets1-Runx1 complexes.The EMBO journal · 2023Article
- Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases.Blood transfusion = Trasfusione del sangue · 2022Article
- Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF.International journal of molecular sciences · 2021Article
- A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.Critical reviews in immunology · 2016Article
- Article
- At the bench: understanding group 2 innate lymphoid cells in disease.Journal of leukocyte biology · 2015Review
- STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.Allergy · 2012Article
- Ets-1 maintains IL-7 receptor expression in peripheral T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Comparative analysis of genome sequences of the Th2 cytokine region of rabbit (Oryctolagus cuniculus) with those of nine different species.Immunology and immunogenetics insights · 2011Article
- An update on the roles of transcription factor Ets1 in autoimmune diseases.WIREs mechanisms of diseaseReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Th2 cytokine gene locus has emerged as a remarkable example of coordinated gene expression, the regulation of which seems to be rooted in an extensive array of cis-regulatory regions. Using a hypothesis-generating computational approach that integrated multispecies (n = 11) sequence comparisons with algorithm-based transcription factor binding-site predictions, we sought to identify evolutionarily conserved noncoding regions (ECRs) and motifs shared among them, which may underlie coregulation. Twenty-two transcription factor families were predicted to have binding sites in at least two Th2 ECRs. The ranking of these shared motifs according to their distribution and relative frequency pointed to a regulatory hierarchy among the transcription factor families. GATA sites were the most prevalent and widely distributed, consistent with the known role of GATA3 as a Th2 master switch. Unexpectedly, sites for ETS-domain proteins were also predicted within several Th2 ECRs and the majority of these sites were found to support Ets-1 binding in vitro and in vivo. Of note, the expression of all three Th2 cytokines (IL-5, -13, and -4) was significantly and selectively decreased in Th2 cells generated from Ets-1-deficient mice. Collectively, these data suggest that Ets-1 contributes to Th2 cytokine gene regulation by interacting with multiple cis-regulatory regions throughout the Th2 locus.
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Registered trials
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