ArticleGenetics2010
The Rim101p/PacC pathway and alkaline pH regulate pattern formation in yeast colonies.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Cell differentiation, aging, and death in spatially organized yeast communities: mechanisms and consequences.Cell death and differentiation · 2025Review
- Spatiotemporal patterns of gene expression during development of a complex colony morphology.PloS one · 2024Article
- Investigating cell autonomy in microorganisms.Current genetics · 2022Article
- Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies.Genetics · 2019Article
- Effects of exogenous salicylic acid and pH on pathogenicity of biotrophy-associated secreted protein 1 (BAS1)-overexpressing strain, Magnaporthe oryzae.Environmental science and pollution research international · 2019Article
- A fully-automated, robust, and versatile algorithm for long-term budding yeast segmentation and tracking.PloS one · 2019Article
- A regulatory circuit of two lncRNAs and a master regulator directs cell fate in yeast.Nature communications · 2018Article
- Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling.BMC genomics · 2017Article
- Shrinking Daughters: Rlm1-Dependent GGenetics · 2017Article
- Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Microbial cell (Graz, Austria) · 2016Article
- Phenotypic plasticity within yeast colonies: differential partitioning of cell fates.Current genetics · 2016Article
- Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway.Genetics · 2015Article
- Coordinate responses to alkaline pH stress in budding yeast.Microbial cell (Graz, Austria) · 2015Review
- Causal variation in yeast sporulation tends to reside in a pathway bottleneck.PLoS genetics · 2014Article
- Silencing is noisy: population and cell level noise in telomere-adjacent genes is dependent on telomere position and sir2.PLoS genetics · 2014Article
- Article
- Strong inter-population cooperation leads to partner intermixing in microbial communities.eLife · 2013Article
- Rapidly developing yeast microcolonies differentiate in a similar way to aging giant colonies.Oxidative medicine and cellular longevity · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Multicellular organisms utilize cell-to-cell signals to build patterns of cell types within embryos, but the ability of fungi to form organized communities has been largely unexplored. Here we report that colonies of the yeast Saccharomyces cerevisiae formed sharply divided layers of sporulating and nonsporulating cells. Sporulation initiated in the colony's interior, and this region expanded upward as the colony matured. Two key activators of sporulation, IME1 and IME2, were initially transcribed in overlapping regions of the colony, and this overlap corresponded to the initial sporulation region. The development of colony sporulation patterns depended on cell-to-cell signals, as demonstrated by chimeric colonies, which contain a mixture of two strains. One such signal is alkaline pH, mediated through the Rim101p/PacC pathway. Meiotic-arrest mutants that increased alkali production stimulated expression of an early meiotic gene in neighboring cells, whereas a mutant that decreased alkali production (cit1Delta) decreased this expression. Addition of alkali to colonies accelerated the expansion of the interior region of sporulation, whereas inactivation of the Rim101p pathway inhibited this expansion. Thus, the Rim101 pathway mediates colony patterning by responding to cell-to-cell pH signals. Cell-to-cell signals coupled with nutrient gradients may allow efficient spore formation and spore dispersal in natural environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.