ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2010
Benefit of kidney transplantation beyond 70 years of age.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Kidney transplant outcomes in patients aged ≥ 70 years: a systematic review and meta-analysis of multicenter or registry-based studies with future directions and a multicenter study proposal.International urology and nephrology · 2026Pooled it
- Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022Pooled it
- Kidney Transplant Referral, Activation, and Transplantation Rates in a Single-Center Cohort of Older Adults in Nova Scotia.Clinical transplantation · 2026Article
- A Prediction Model for Risk of Death in Kidney Transplant Recipients.JAMA network open · 2026Article
- "Rethinking High-KDPI Kidneys: A Multidomain Approach to Predicting Success".Clinical transplantation · 2026Article
- A communication-efficient federated learning algorithm to assess racial disparities in post-transplantation survival time.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Article
- Immunosuppressant-Induced Alteration of Gut Microbiota Causes Loss of Skeletal Muscle Mass: Evidence from Animal Experiments Using Mice and Observational Study on Humans.Journal of clinical medicine · 2025Article
- Serum Trimethylamine N-Oxide Levels as a Predictor of Peripheral Arterial Disease in Kidney Transplant Recipients.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- Machine Perfusion in an Ageing Population - Results From a German, National Survey Among Transplant Centers.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Better kidney allograft survival despite higher-risk donor and recipient characteristics between 1995 and 2014.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Outcomes of Older Primary Kidney Transplant Recipients by Induction Agent and High-risk Viral Discordance Status in the United States.Transplantation direct · 2024Article
- Long-term Outcomes After Kidney Transplantation From DBD Donors Aged 70 y and Older.Transplantation direct · 2024Article
- COVID-19 and Access to Kidney Transplantation for Older Candidates in the United States: A National Registry Study.Kidney medicine · 2024Article
- Benefits of Living Over Deceased Donor Kidney Transplantation in Elderly Recipients. A Propensity Score Matched Analysis of a Large European Registry Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2024Observational
- Kidney Transplantation Improves Health-Related Quality of Life in Older Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Outcomes of and indications for renal transplantation in patients with von Hippel Lindau disease.Urologic oncology · 2023Article
- Evolving Trends in Kidney Transplant Outcomes Among Older Adults: A Comparative Analysis Before and During the COVID-19 Pandemic.Transplantation direct · 2023Article
- Potassium canrenoate in brain-dead organ donors: a randomised controlled clinical trial protocol (CANREO-PMO).BMJ open · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney transplantation generally improves long-term survival in patients with end-stage renal disease. However, in patients older than 70 years of age, only limited data are available that directly compare the potential survival benefit of transplantation versus dialysis.
methodsAll patients aged above 70 years who started dialysis between 1990 and 2005 and were waitlisted for kidney transplantation were included in the study. They were categorized according to time periods of inclusion (1990-99 vs 2000-05). Survival rates of altogether 286 dialysis patients were analyzed with a Kaplan-Meier model, as well as with a time-dependent Cox model. Comparisons were made between those who received a transplant and those who did not, and further between the two time periods.
resultsMedian age at inclusion was 73.6 years (interquartile range 72.3-75.6). Two hundred and thirty-three patients (81%) received a kidney transplant during follow-up. Transplant recipients experienced an increased mortality in the first year after transplantation when compared to waitlisted patients. Patients starting dialysis between 1990 and 1999 had no significant long-term benefit of transplantation; HR for death 1.01 (0.58-1.75). In contrast, there was a substantial long-term benefit of transplantation among those starting dialysis after 2000; HR for death 0.40 (0.19-0.83), P = 0.014.
conclusionsSurvival after kidney transplantation in patients over 70 years has improved during the last decade and offers a survival advantage over dialysis treatment. Our experience supports the use of kidney transplantation in this age group if an increased early post-operative risk is accepted. This transplant policy may be challenged for priority reasons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.