ArticleRespiratory physiology & neurobiology2010
Structure-function studies of blood and air capillaries in chicken lung using 3D electron microscopy.
Article in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
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- Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy.Connective tissue research · 2021Article
- Volume electron microscopy: analyzing the lung.Histochemistry and cell biology · 2021Review
- Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Determination of secretory granule maturation times in pancreatic islet β-cells by serial block-face electron microscopy.Journal of structural biology · 2020Article
- Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2.The Journal of cell biology · 2020Article
- TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.JCI insight · 2019Article
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- Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.Life science alliance · 2018Article
- Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography.Journal of structural biology · 2018Article
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- Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.Journal of cell science · 2018Article
- REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking.Human molecular genetics · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Avian pulmonary capillaries differ from those of mammals in three important ways. The blood-gas barrier is much thinner, it is more uniform in thickness, and the capillaries are far more rigid when their transmural pressure is altered. The thinness of the barrier is surprising because it predisposes the capillaries to stress failure. A possible mechanism for these differences is that avian pulmonary capillaries, unlike mammalian, are supported from the outside by air capillaries, but the details of the support are poorly understood. To clarify this we studied the blood and air capillaries in chicken lung using transmission electron microscopy (EM) and two relatively new techniques that allow 3D visualization: electron tomography and serial block-face scanning EM. These studies show that the pulmonary capillaries are flanked by epithelial bridges composed of two extremely thin epithelial cells with large surface areas. The junctions of the bridges with the capillary walls show thickening of the epithelial cells and an accumulation of extracellular matrix. Collapse of the pulmonary capillaries when the pressure outside them is increased is apparently prevented by the guy wire-like action of the epithelial bridges. The enlarged junctions between the bridges and the walls could provide a mechanism that limits the hoop stress in the capillary walls when the pressure inside them is increased. The support of the pulmonary capillaries may also be explained by an interdependence mechanism whereby the capillaries are linked to a rigid assemblage of air capillaries. These EM studies show the supporting structures in greater detail than has previously been possible, particularly in 3D, and they allow a more complete analysis of the mechanical forces affecting avian pulmonary capillaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.