ArticleBiomacromolecules2010
Amelogenin nanoparticles in suspension: deviations from spherical shape and pH-dependent aggregation.
Article in Biomacromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- SAXS of murine amelogenin identifies a persistent dimeric species from pH 5.0 to 8.0.Journal of structural biology · 2024Article
- Role of amelogenin phosphorylation in regulating dental enamel formation.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Preparative SDS PAGE as an Alternative to His-Tag Purification of Recombinant Amelogenin.Frontiers in physiology · 2017Article
- MMP20 Proteolysis of Native Amelogenin Regulates Mineralization In Vitro.Journal of dental research · 2016Article
- Dynamic interactions of amelogenin with hydroxyapatite surfaces are dependent on protein phosphorylation and solution pH.Colloids and surfaces. B, Biointerfaces · 2016Article
- TGF-β1 autocrine signalling and enamel matrix components.Scientific reports · 2016Article
- Amelogenin in Enamel Tissue Engineering.Advances in experimental medicine and biology · 2015Article
- Article
- Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus.Biochemistry · 2013Article
- Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils.Biomacromolecules · 2012Article
- Structural changes in amelogenin upon self-assembly and mineral interactions.Journal of dental research · 2012Article
- Effect of phosphorylation on the interaction of calcium with leucine-rich amelogenin peptide.European journal of oral sciences · 2011Article
- Self-assembly of amelogenin proteins at the water-oil interface.European journal of oral sciences · 2011Article
- In situ AFM study of amelogenin assembly and disassembly dynamics on charged surfaces provides insights on matrix protein self-assembly.Journal of the American Chemical Society · 2011Article
- Leucine-rich amelogenin peptides regulate mineralization in vitro.Journal of dental research · 2011Article
- Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Single-molecule determination of the face-specific adsorption of Amelogenin's C-terminus on hydroxyapatite.Angewandte Chemie (International ed. in English) · 2011Article
- Self-aligning amelogenin nanoribbons in oil-water system.Journal of structural biology · 2011Article
- Effects of phosphorylation on the self-assembly of native full-length porcine amelogenin and its regulation of calcium phosphate formation in vitro.Journal of structural biology · 2011Article
- Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.PloS one · 2011Article
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Authors and funding
8 authors.
Funding
Abstract
It is well-known that amelogenin self-assembles to form nanoparticles, usually referred to as amelogenin nanospheres, despite the fact that not much is known about their actual shape in solution. In the current paper, we combine SAXS and DLS to study the three-dimensional shape of the recombinant amelogenins rP172 and rM179. Our results show for the first time that amelogenins build oblate nanoparticles in suspension using experimental approaches that do not require the proteins to be in contact with a support material surface. The SAXS studies give evidence for the existence of isolated amelogenin nano-oblates with aspect ratios in the range of 0.45-0.5 at pH values higher than pH 7.2 and show an aggregation of these nano-oblates at lower pH values. The role of the observed oblate shape in the formation of chain-like structures at physiological conditions is discussed as a key factor in the biomineralization of dental enamel.
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