ArticleDepression and anxiety2010
NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.
Article in Depression and anxiety, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study.The Journal of clinical psychiatry · 2014Trial
- The Mental Health Impacts of Wildfire Exposure: A Scoping Review of the Quantitative Evidence.Current environmental health reports · 2026Article
- Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs.Drug design, development and therapy · 2024Review
- Projecting the Impacts of a Changing Climate: Tropical Cyclones and Flooding.Current environmental health reports · 2022Review
- Exposure Assessment for Tropical Cyclone Epidemiology.Current environmental health reports · 2022Review
- Mediating Effect of Emotional and Social Competences on Interrelations Between Gender, Age and the Broad Autism Phenotype.Journal of autism and developmental disorders · 2021Article
- The Silent Pandemic: The Psychological Burden on Frontline Healthcare Workers during COVID-19.Psychiatry journal · 2021Review
- Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Pancreatic Polypeptide but Not Other Members of the Neuropeptide Y Family Shows a Moderate Association With Perceived Anxiety in Obese Men.Frontiers in human neuroscience · 2020Article
- Assessment of depression-like behavior and anhedonia after repeated cycles of binge-like ethanol drinking in male C57BL/6J mice.Pharmacology, biochemistry, and behavior · 2018Article
- Prevalence Rates and Predictors of Generalized Anxiety Disorder Symptoms in Residents of Fort McMurray Six Months After a Wildfire.Frontiers in psychiatry · 2018Article
- Genetics of generalized anxiety disorder and related traits.Dialogues in clinical neuroscience · 2017Review
- Biological markers of generalized anxiety disorder.Dialogues in clinical neuroscience · 2017Review
- Association of neuropeptide Y promoter polymorphism (rs16147) with perceived stress and cardiac vagal outflow in humans.Scientific reports · 2016Article
- Neuropeptide Y: A stressful review.Neuropeptides · 2016Review
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.Neurobiology of stress · 2015Article
- NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- A Pilot Study on Playback Theatre as a Therapeutic Aid after Natural Disasters: Brain Connectivity Mechanisms of Effects on Anxiety.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNeuropeptide Y (NPY) has been found to be anxiolytic in animals and humans. A recent study found NPY expression to be inversely correlated with trait anxiety. We examined whether rs16147, a functional single nucleotide polymorphism in the promoter region of NPY, moderated the relationship between hurricane exposure and risk for generalized anxiety disorder (GAD) in an epidemiologic sample of adults living in areas affected by the 2004 Florida hurricanes.
methodsData from this study comes from 616 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. Selection of participants occurred via random digit-dial procedures. Participants were interviewed via telephone about hurricane exposure and post-hurricane GAD symptoms. The outcome measure was DSM-IV GAD diagnosis, assessed via structured interview.
resultsRs16147 in NPY was associated with increased risk of GAD diagnosis under conditions of high hurricane exposure (P<.01). This gene by environment interaction remained significant after adjustment for sex, ancestry (as determined by Bayesian clustering of genotypes), and age.
conclusionsNPY rs16147 modifies risk of post-disaster GAD under conditions of high stressor (hurricane) exposure. This is the first demonstration of gene-environment interaction for this locus.
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