ArticleComparative and functional genomics2009
Association of interleukin-8 with cachexia from patients with low-third gastric cancer.
Article in Comparative and functional genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- -251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies.Molecular biology reports · 2012Pooled it
- A meta-analysis of interleukin-8 -251 promoter polymorphism associated with gastric cancer risk.PloS one · 2012Pooled it
- Review
- The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer.Cancer reports (Hoboken, N.J.) · 2025Article
- Influence of Cytokine Genetic Polymorphisms inGut and liver · 2024Article
- Cancer anorexia-cachexia syndrome is characterized by more than one inflammatory pathway.Journal of cachexia, sarcopenia and muscle · 2024Article
- The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.Journal of cachexia, sarcopenia and muscle · 2021Article
- The expression landscape of cachexia-inducing factors in human cancers.Journal of cachexia, sarcopenia and muscle · 2020Article
- Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.Journal of cachexia, sarcopenia and muscle · 2020Review
- Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.Cancers · 2020Article
- Article
- Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.International journal of molecular sciences · 2018Article
- Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes.Journal of clinical medicine · 2018Article
- Article
- Protein calorie malnutrition, nutritional intervention and personalized cancer care.Oncotarget · 2017Review
- Article
- Article
- Association between Interleukin-8-251A/T polymorphism and gastric cancer susceptibility: a meta-analysis based on 5286 cases and 8000 controls.International journal of clinical and experimental medicine · 2015Article
- Genetic polymorphisms in inflammatory response genes and their associations with breast cancer risk.Croatian medical journal · 2014Article
- Association of interleukin-8 gene polymorphisms with the risk of hepatocellular carcinoma.Molecular biology reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Interleukin (IL)-8 has been implicated in the development of cancer cachexia. The polymorphism of IL-8 gene, which may affect the production level of IL-8, may be associated with cancer cachexia. Methods. The serum IL-8 level in our study was examined by radioimmunoassay. We also analyzed single nucleotide polymorphisms (SNPs) -251 A/T and +781 C/T of IL-8 gene, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results. The serum levels of IL-8 were significantly elevated in patients with low-third gastric cancer compared with controls, and were further up-regulated in patients with cachexia than those without (Z = -3.134, P = .002). A significantly increased frequency of +781 T allele was noted in patients with cachexia (OR = 2.247, 95% CI: 1.351-3.737, P = .002). The +781 TT genotype was observed to be associated with a significantly increased risk of cachexia (OR = 3.167, 95% CI: 1.265-7.929, P = .011), and with odds ratio of 3.033 (95% CI: 1.065-8.639, P = .038) for cachexia after adjusting for potential confounding factors. Meanwhile, haplotype analysis indicated a borderline positive association between T(251)T(781) haplotype and cachexia as compared with the T(251)C(781) haplotype (OR = 4.92, 95% CI: 1.00-24.28; ,P = .053). Conclusions. IL-8 appears to be associated with cachexia from patients with low-third gastric cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.