ArticleAsian journal of andrology2010
Scoring of sperm chromosomal abnormalities by manual and automated approaches: qualitative and quantitative comparisons.
Article in Asian journal of andrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Male infertility: establishing sperm aneuploidy thresholds in the laboratory.Journal of assisted reproduction and genetics · 2019Review
- Environmental exposure to pyrethroids and sperm sex chromosome disomy: a cross-sectional study.Environmental health : a global access science source · 2013Article
- FISH and tips: a large scale analysis of automated versus manual scoring for sperm aneuploidy detection.Basic and clinical andrology · 2013Article
- The association between sperm sex chromosome disomy and semen concentration, motility and morphology.Human reproduction (Oxford, England) · 2012Article
- Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy.Environmental health perspectives · 2012Article
- Semi-automated scoring of triple-probe FISH in human sperm: methods and further validation.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2011Article
- Robertsonian and Balanced Reciprocal Translocation in Both Child and Mother with a History of Recurrent Abortions.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now well known that levels of sperm disomy correlate to levels of infertility (as well as other factors). The risk of perpetuating aneuploidy to the offspring of infertile males undergoing intracytoplasmic sperm injection (ICSI) has become a hotly debated issue in assisted reproduction; however, there remain barriers to the practical implementation of offering sperm disomy screening in a clinical setting. The major barrier is the operator time taken to analyze a statistically meaningful (sufficient) number of cells. The introduction of automated 'spot counting' software-hardware combinations presents a potential solution to this problem. In this preliminary validation study, we analyzed 10 patients, both manually and using a commercially available spot counter. Results show a statistically significant correlation between both approaches for scoring of sperm disomy, but no correlation is found when scoring for diploid sperm. The most likely explanation for the latter is an apparent overscoring of two closely associated sperm heads as a single diploid cell. These results, and similar further studies that will ensue, help to inform cost-benefit analyses that individual clinics need to carry out in order to decide whether to adopt sperm aneuploidy screening as a routine tool for the assessment of sperm from men requiring ICSI treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.