ArticleThe Journal of biological chemistry2010
Cell-penetrating peptides with intracellular actin-remodeling activity in malignant fibroblasts.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs.Tissue barriers · 2022Review
- Advancement of Peptide Nanobiotechnology via Emerging Microfluidic Technology.Micromachines · 2019Review
- Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.International journal of molecular sciences · 2019Article
- Cholesterol re-organisation and lipid de-packing by arginine-rich cell penetrating peptides: Role in membrane translocation.PloS one · 2019Article
- Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates.Scientific reports · 2018Article
- Pronounced peptide selectivity for melanoma through tryptophan end-tagging.Scientific reports · 2016Article
- Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)EuPA open proteomics · 2016Article
- Photocross-Linked Peptide-Protein Complexes Analysis: A Comparative Study of CID and ETD Fragmentation Modes.Journal of the American Society for Mass Spectrometry · 2015Article
- Amphiphilic macromolecules on cell membranes: from protective layers to controlled permeabilization.The Journal of membrane biology · 2014Review
- A knockdown mutation of YELLOW-GREEN LEAF2 blocks chlorophyll biosynthesis in rice.Plant cell reports · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-penetrating peptides can cross cell membranes and are commonly seen as biologically inert molecules. However, we found that some cell-penetrating peptides could remodel actin cytoskeleton in oncogene-transformed NIH3T3/EWS-Fli cells. These cells have profound actin disorganization related to their tumoral transformation. These arginine- and/or tryptophan-rich peptides could cross cell membrane and induce stress fiber formation in these malignant cells, whereas they had no perceptible effect in non-tumoral fibroblasts. In addition, motility (migration speed, random motility coefficient, wound healing) of the tumor cells could be decreased by the cell-permeant peptides. Although the peptides differently influenced actin polymerization in vitro, they could directly bind monomeric actin as determined by NMR and calorimetry studies. Therefore, cell-penetrating peptides might interact with intracellular protein partners, such as actin. In addition, the fact that they could reverse the tumoral phenotype is of interest for therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.