ArticleAJNR. American journal of neuroradiology2010
Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
REGISTRY-JHD - an Observational Study of the European Huntington's Disease Network (EHDN)
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Disentangling the Effects of Spinal Cord Injury and Related Neuropathic Pain on Supraspinal Neuroplasticity: A Systematic Review on Neuroimaging.Frontiers in neurology · 2019Pooled it
- Is intracranial volume a suitable proxy for brain reserve?Alzheimer's research & therapy · 2018Pooled it
- Voxel-based morphometry for separation of schizophrenia from other types of psychosis in first episode psychosis.The Cochrane database of systematic reviews · 2015Pooled it
- Mapping Focal and Generalized Effects of Common Genetic Variants on Human Brain Structure.bioRxiv : the preprint server for biology · 2026Article
- Geometric properties of caudate and putamen mark the progression of Huntington's disease.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- MRI evidence of gray matter loss in COVID-19 patients with cognitive and olfactory disorders.Annals of clinical and translational neurology · 2024Article
- Cortical changes in the brain of patients with hemifacial spasm.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.Molecular psychiatry · 2024Article
- Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease.Neuroprotection (Chichester, England) · 2023Article
- Resting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expression.Brain imaging and behavior · 2023Article
- Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Structural and functional neuroimaging of the effects of the gut microbiome.European radiology · 2022Review
- Hippocampal connectivity in Amyotrophic Lateral Sclerosis (ALS): more than Papez circuit impairment.Brain imaging and behavior · 2021Article
- Focusing on Comorbidity-A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders.Frontiers in psychiatry · 2021Article
- Understanding Cluster Headache Using Magnetic Resonance Imaging.Frontiers in neurology · 2020Review
- Associations Between Individual Differences in Mathematical Competencies and Surface Anatomy of the Adult Brain.Frontiers in human neuroscience · 2020Article
- A whole-body FDG PET/MR atlas for multiparametric voxel-based analysis.Scientific reports · 2019Article
- Reduced resilience of brain gray matter networks in idiopathic generalized epilepsy: A graph-theoretical analysis.PloS one · 2019Article
- Automated Generation of Radiologic Descriptions on Brain Volume Changes From T1-Weighted MR Images: Initial Assessment of Feasibility.Frontiers in neurology · 2019Article
- Praising others differently: neuroanatomical correlates to individual differences in trait gratitude and elevation.Social cognitive and affective neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
background and purposeVBM is increasingly used in the study of neurodegeneration, and recently there has been interest in its potential as a biomarker. However, although it is largely "automated," VBM is rarely implemented consistently across studies, and changing user-specified options can alter the results in a way similar to the very biologic differences under investigation. MATERIALS AND
methodsThis work uses data from patients with HD to demonstrate the effects of several user-specified VBM parameters and analyses: type and level of statistical correction, modulation, smoothing kernel size, adjustment for brain size, subgroup analysis, and software version.
resultsThe results demonstrate that changing these options can alter results in a way similar to the biologic differences under investigation.
conclusionsIf VBM is to be useful clinically or considered for use as a biomarker, there is a need for greater recognition of these issues and more uniformity in its application for the method to be both reproducible and valid.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.