Evidence map›Paper›PMID 20036977›Full record

ReviewFrontiers in bioscience (Scholar edition)2010

Mechanisms and controllers of eccrine sweating in humans.

Manabu Shibasaki, Craig G Crandall

Open access · bronzeAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Scholar edition), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 197 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Neuropeptides and the Autonomic Nervous System in Prader-Willi Syndrome.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Manabu ShibasakiDepartment of Environmental and Life Sciences, Nara Women's University Graduate School of Humanities and Sciences, Nara Japan.
Craig G Crandall
Institute for Exercise and Environmental Medicine · US

Funding

HYPERTHERMIA EFFECTS ON HUMAN BAROFLEX FUNCTIONR01HL061388 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 1999 to 2011
$2.4M
Neural and non-neural modulators of skin blood flow and sweating in humansR01HL084072 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2006 to 2009
$1.3M
NHLBI NIH HHS HL-61388NHLBI NIH HHS R01 HL061388NHLBI NIH HHS R01 HL084072PHS HHS 84072
6 · The paper itself

Abstract

Human body temperature is regulated within a very narrow range. When exposed to hyperthermic conditions, via environmental factors and/or increased metabolism, heat dissipation becomes vital for survival. In humans, the primary mechanism of heat dissipation, particularly when ambient temperature is higher than skin temperature, is evaporative heat loss secondary to sweat secretion from eccrine glands. While the primary controller of sweating is the integration between internal and skin temperatures, a number of non-thermal factors modulate the sweating response. In addition to summarizing the current understanding of the neural pathways from the brain to the sweat gland, as well as responses at the sweat gland, this review will highlight findings pertaining to studies of proposed non-thermal modifiers of sweating, namely, exercise, baroreceptor loading state, and body fluid status. Information from these studies not only provides important insight pertaining to the basic mechanisms of sweating, but also perhaps could be useful towards a greater understanding of potential mechanisms and consequences of disease states as well as aging in altering sweating responses and thus temperature regulation.

Indexed as

Body FluidsEccrine GlandsExerciseHumansHypothalamusNeural PathwaysOsmolar ConcentrationPressoreceptorsSweating

Identifiers

PMID20036977
PMCPMC2866164
OpenAlexW2091022667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.