ReviewFrontiers in bioscience (Elite edition)2010
Cardiovascular responses to cold exposure.
Review in Frontiers in bioscience (Elite edition), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Responses to Cold Exposure in Hypertension
Year-round Health Enhancing Exercise and Coronary Artery Disease: Randomized Controlled Study
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Association between ambient temperature and risk of stroke morbidity and mortality: A systematic review and meta-analysis.Brain and behavior · 2023Pooled it
- Reproducibility of blood pressure response to the cold pressor test: the GenSalt Study.American journal of epidemiology · 2012Trial
- Article
- Associations of extreme temperature and relative humidity with hematological disease mortality in Chuzhou, China.Scientific reports · 2026Article
- Short-term gaseous and particulate air pollution exposure and risk of acute kidney injury: a 12-year case-crossover study [2013-2024] in Guangzhou, China.Journal of thoracic disease · 2026Article
- Baseline vagal tone and pain reactivity: linking autonomic function to endogenous pain inhibition in women.Pain reports · 2026Article
- MiR-499-5P/PACS2/TRPV1 Axis Maintains Mitochondrial Homeostasis and Left Ventricular Function after Extreme Cold Stress.Journal of cardiovascular translational research · 2026Article
- Ambient Temperature and Risk of Renal Colic: A Systematic Review and Meta-analysis.Kidney medicine · 2026Article
- The involvement of attentional biases in endogenous pain inhibition and autonomic reactivity.PloS one · 2026Article
- Low climate-patterned temperature and cardiovascular disease: Worldwide trends and implications for public health policy.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Sex Differences in Seasonal Variation in Metabolic Syndrome and Its Components: A 10-Year National Health Screening Study.Journal of clinical medicine · 2025Article
- Cold Exposure Exacerbates Cardiac Dysfunction in a Model of Heart Failure with Preserved Ejection Fraction in Male and Female C57Bl/6J Mice.Biomedicines · 2025Article
- Ambient Temperature and the Frequency of Subsequent Heart Failure Decompensations in an Emergency Department.Biomedicines · 2025Article
- Neurological and mental health in the era of climate change: mechanisms, clinical impacts, and adaptation.Frontiers in public health · 2025Review
- Chronic cold exposure causes left ventricular hypertrophy that appears to be physiological.The Journal of experimental biology · 2024Article
- Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes.Scientific reports · 2024Article
- Healthy Aging in Times of Extreme Temperatures: Biomedical Approaches.Aging and disease · 2024Review
- Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity.Journal of clinical medicine · 2024Review
- Heavy Metal Scavenger Metallothionein Rescues Against Cold Stress-Evoked Myocardial Contractile Anomalies Through Regulation of Mitophagy.Cardiovascular toxicology · 2024Article
- The Impact of Climate Change and Extreme Weather Conditions on Cardiovascular Health and Acute Cardiovascular Diseases.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The prevalence of hypertension is increased in winter and in cold regions of the world. Cold temperatures make hypertension worse and trigger cardiovascular complications (stroke, myocardial infarction, heart failure, etc.). Chronic or intermittent exposure to cold causes hypertension and cardiac hypertrophy in animals. The purpose of this review is to provide the recent advances in the mechanistic investigation of cold-induced hypertension (CIH). Cold temperatures increase the activities of the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS). The SNS initiates CIH via the RAS. Cold exposure suppresses the expression of eNOS and formation of NO, increases the production of endothelin-1 (ET-1), up-regulates ETA receptors, but down-regulates ETB receptors. The roles of these factors and their relations in CIH will be reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.