ArticleRespiratory physiology & neurobiology2010
Differential expression of respiratory long-term facilitation among inbred rat strains.
Article in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Quantitative assessment of integrated phrenic nerve activity.Respiratory physiology & neurobiology · 2016Pooled it
- Influence of chronic hypoxia on the hypoxic ventilatory response of juvenile and adult rats.Respiratory physiology & neurobiology · 2023Article
- APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia.bioRxiv : the preprint server for biology · 2023Article
- APOE4, Age, and Sex Regulate Respiratory Plasticity Elicited by Acute Intermittent Hypercapnic-Hypoxia.Function (Oxford, England) · 2023Article
- Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep.Physiological reports · 2022Article
- Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.Experimental neurology · 2022Article
- Effects of allergic airway inflammation and chronic intermittent hypoxia on systemic blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms.Respiratory physiology & neurobiology · 2018Article
- Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.Respiratory physiology & neurobiology · 2018Article
- Enhancement of phrenic long-term facilitation following repetitive acute intermittent hypoxia is blocked by the glycolytic inhibitor 2-deoxyglucose.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Intraspinal transplantation of subventricular zone-derived neural progenitor cells improves phrenic motor output after high cervical spinal cord injury.Experimental neurology · 2017Article
- Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis.Comprehensive Physiology · 2016Review
- Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure.Respiratory physiology & neurobiology · 2015Article
- Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Fluoxetine augments ventilatory CO2 sensitivity in Brown Norway but not Sprague Dawley rats.Respiratory physiology & neurobiology · 2013Article
- Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia.F1000prime reports · 2013Article
- Similarities and differences in mechanisms of phrenic and hypoglossal motor facilitation.Respiratory physiology & neurobiology · 2011Review
- Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Experimental protocols and preparations to study respiratory long term facilitation.Respiratory physiology & neurobiology · 2011Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypotheses that: (1) long-term facilitation (LTF) following acute intermittent hypoxia (AIH) varies among three inbred rat strains: Fischer 344 (F344), Brown Norway (BN) and Lewis rats and (2) ventral cervical spinal levels of genes important for phrenic LTF (pLTF) vary in association with pLTF magnitude. Lewis and F344, but not BN rats exhibited significant increases in phrenic and hypoglossal burst amplitude 60min post-AIH that were significantly greater than control experiments without AIH, indicating strain differences in phrenic (98%, 56% and 20%, respectively) and hypoglossal LTF (66%, 77% and 5%, respectively). Ventral spinal 5-HT(2A) receptor mRNA and protein levels were higher in F344 and Lewis versus BN, suggesting that higher 5-HT(2A) receptor levels are associated with greater pLTF. More complex relationships were found for 5-HT(7), BDNF and TrkB mRNA. BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.