ArticleNeuroscience2010
Cortico-cerebellar coherence and causal connectivity during slow-wave activity.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study.Cerebellum (London, England) · 2026Article
- Investigating the causal relationship between multimodal brain imaging-derived phenotypes and insomnia: A Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024Review
- What Is the Involvement of the Cerebellum During Sleep?Neurology · 2023Article
- Conserved Population Dynamics in the Cerebro-Cerebellar System between Waking and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- Effect of detoxification on N3 sleep correlates with brain functional but not structural changes in alcohol use disorder.Drug and alcohol dependence · 2022Article
- Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mice Lacking Cerebellar Cortex and Related Structures Show a Decrease in Slow-Wave Activity With Normal Non-REM Sleep Amount and Sleep Homeostasis.Frontiers in behavioral neuroscience · 2022Article
- Cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor.Heliyon · 2021Article
- Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder.Translational psychiatry · 2021Article
- Communication from the cerebellum to the neocortex during sleep spindles.Progress in neurobiology · 2021Article
- Perspective on the Multiple Pathways to Changing Brain States.Frontiers in systems neuroscience · 2020Review
- Article
- Cerebellar Lobulus Simplex and Crus I Differentially Represent Phase and Phase Difference of Prefrontal Cortical and Hippocampal Oscillations.Cell reports · 2019Article
- Linking Essential Tremor to the Cerebellum: Physiological Evidence.Cerebellum (London, England) · 2016Review
- In vivo differences in inputs and spiking between neurons in lobules VI/VII of neocerebellum and lobule X of archaeocerebellum.Cerebellum (London, England) · 2015Article
- Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements.Nature neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cerebral cortical slow-wave activity (SWA) is prominent during sleep and also during ketamine-induced anesthesia. SWA in electroencephalogram (EEG) recordings is closely linked to prominent fluctuations between up- and down-states in the membrane potential of pyramidal neurons. However, little is known about how the cerebellum is linked into SWA and whether slow cortical oscillations influence sensory cerebellar responses. To examine these issues, we simultaneously recorded EEG activity from the cerebral cortex (SI, MI, and supplementary motor area (SMA)), local field potentials at the input stage of cerebellar processing in the cerebellar granule cell layer (GCL) and inferior olive (IO), and single unit activity at the output stage of the cerebellum in the deep cerebellar nuclei (DCN). We found that in ketamine-anesthetized rats, SWA was synchronized between all recorded cortical areas and was phase locked with local field potentials of the GCL, IO and single unit activity in the DCN. We also found that cortical up-states are linked to activation of GCL neurons but to inhibition of cerebellar output from the DCN, with the latter an effect likely mediated by Purkinje cells. A partial coherence analysis showed further that a large portion of SWA shared between GCL and DCN was transmitted from the cortex, since the coherence shared between GCL and DCN was diminished when the effect of cortical activity was subtracted. To determine the causal flow of information between structures, a directed transfer function was calculated between the simultaneous activities of SI, MI, SMA, GCL and DCN. This analysis demonstrated that the primary direction of information flow was from cortex to the cerebellum and that SI had a stronger influence than other cortical areas on DCN activity. The strong functional connectivity with SI in particular is in agreement with previous findings of a strong cortical component in cerebellar sensory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.