Evidence map›Paper›PMID 20036327›Full record

ReviewThe Journal of steroid biochemistry and molecular biology2010

Insulin and hyperandrogenism in women with polycystic ovary syndrome.

Catherine G Baptiste, Marie-Claude Battista, Andréanne Trottier, Jean-Patrice Baillargeon

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of steroid biochemistry and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 123 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 13 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01246310 naterminatednot on this map

Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients.

TypeinterventionalSponsorAGUNCO Obstetrics and Gynecology CentreRan2010 to 2022Enrolled24ConditionsDepression, PCOSArmsInositol, Placebo
NCT04881851 naterminatednot on this mapstarted 2015, after this paper: background citation

Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment

TypeinterventionalSponsorUniversita di VeronaRan2015 to 2025Enrolled76ConditionsPolycystic Ovary SyndromeArmsInositol + alpha lipoic acid, Inositol, Folic acid (placebo comparator)
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 13 syntheses or guidelines pooled it, 343 citations in OpenAlex.

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  16. Changes in Ghrelin and Glucagon following a Low Glycemic Load Diet in Women with PCOS.The Journal of clinical endocrinology and metabolism · 2021
    Trial
  17. Article
  18. Article
  19. Molecules (Basel, Switzerland) · 2026
    Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Catherine G BaptisteDepartment of Medicine, Division of Endocrinology, University of Sherbrooke, 3001 12th North Avenue, Sherbrooke, QC J1H 5N4, Canada.
Marie-Claude Battista
Andréanne Trottier
Jean-Patrice Baillargeon
Université de Sherbrooke · CA

Funding

CIHR 94420-1
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a very common endocrine disorder characterized by chronic anovulation, clinical and/or biochemical hyperandrogenism, and/or polycystic ovaries. But most experts consider that hyperandrogenism is the main characteristic of PCOS. Several theories propose different mechanisms to explain PCOS manifestations: (1) a primary enzymatic default in the ovarian and/or adrenal steroidogenesis; (2) an impairment in gonadotropin releasing hormone (GnRH) secretion that promotes luteal hormone (LH) secretion; or (3) alterations in insulin actions that lead to insulin resistance with compensatory hyperinsulinemia. However, in the past 20 years there has been growing evidence supporting that defects in insulin actions or in the insulin signalling pathways are central in the pathogenesis of the syndrome. Indeed, most women with PCOS are metabolically insulin resistant, in part due to genetic predisposition and in part secondary to obesity. But some women with typical PCOS do not display insulin resistance, which supports the hypothesis of a genetic predisposition specific to PCOS that would be revealed by the development of insulin resistance and compensatory hyperinsulinemia in most, but not all, women with PCOS. However, these hypotheses are not yet appropriately confirmed, and more research is still needed to unravel the true pathogenesis underlying this syndrome. The present review thus aims at discussing new concepts and findings regarding insulin actions in PCOS women and how it is related to hyperandrogenemia.

Indexed as

FemaleGenetic Predisposition to DiseaseHumansHyperandrogenismHyperinsulinismInsulinInsulin ResistancePolycystic Ovary SyndromeSteroid 17-alpha-HydroxylaseWeight LossCYP17A1 protein, humanInsulinSteroid 17-alpha-Hydroxylase

Identifiers

PMID20036327
PMCPMC3846536
OpenAlexW2053450620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.