ArticleBiomaterials2010
Convection-driven generation of long-range material gradients.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Gradient scaffolds in bone-soft tissue interface engineering: Structural characteristics, fabrication techniques, and emerging trends.Journal of orthopaedic translation · 2025Review
- Gradient Hydrogels.Advances in biochemical engineering/biotechnology · 2021Article
- Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds.Ultrasonics sonochemistry · 2020Article
- Guided cellular orientation concurrently with cell density gradient on butterfly wings.RSC advances · 2019Article
- Multimaterial Segmented Fiber Printing for Gradient Tissue Engineering.Tissue engineering. Part C, Methods · 2019Article
- Gradient Material Strategies for Hydrogel Optimization in Tissue Engineering Applications.High-throughput · 2018Review
- Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche.Tissue engineering. Part A · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs.Advanced healthcare materials · 2017Article
- Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications.Gels (Basel, Switzerland) · 2016Review
- Microfluidic 3D models of cancer.Advanced drug delivery reviews · 2014Review
- Biochemical and physical signal gradients in hydrogels to control stem cell behavior.Advanced materials (Deerfield Beach, Fla.) · 2013Article
- Gradients of physical and biochemical cues on polyelectrolyte multilayer films generated via microfluidics.Lab on a chip · 2013Article
- The expanding world of tissue engineering: the building blocks and new applications of tissue engineered constructs.IEEE reviews in biomedical engineering · 2013Review
- Microfabricated biomaterials for engineering 3D tissues.Advanced materials (Deerfield Beach, Fla.) · 2012Review
- Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels.Lab on a chip · 2012Article
- Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D microgel synthesis.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- An integrated microfluidic device for two-dimensional combinatorial dilution.Lab on a chip · 2011Article
- Anisotropic material synthesis by capillary flow in a fluid stripe.Biomaterials · 2011Article
- Nanoscale tissue engineering: spatial control over cell-materials interactions.Nanotechnology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter gradients of biomolecules, polymers, beads and cells and cross-gradients of two species in a microchannel. Accompanying theoretical estimates and simulations of gradient growth provide design criteria over a range of material properties. A poly(ethylene-glycol) hydrogel gradient, a porous collagen gradient and a composite material with a hyaluronic acid/gelatin cross-gradient were generated with continuous variations in material properties and in their ability to regulate cellular response. This simple yet generic fluidic platform should prove useful for creating anisotropic biomimetic materials and high-throughput platforms for investigating cell-microenvironment interactions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.