ReviewBiochimica et biophysica acta2010
Genetics of hypertension: from experimental animals to humans.
Review in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Analysis of early hypertension and clinical outcome with bevacizumab: results from seven phase III studies.The oncologist · 2013Trial
- Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals.Medicina (Kaunas, Lithuania) · 2025Article
- Perfluorooctane Sulfonate Exposure Induces Cardiovascular Dysfunction in Female Rats: Role of Ovaries.Cardiology and cardiovascular medicine · 2024Article
- Sex differences in preclinical models of hypertension.Journal of human hypertension · 2023Review
- Association study ofFrontiers in genetics · 2023Article
- Maternally Inherited Essential Hypertension: Adding Further Complexity to an Already Complex Condition.American journal of hypertension · 2022Article
- The Anti-apoptotic Role of 3'-Untranslational Region in Response to Angiotensin II via Mcl1 Expression.Frontiers in cell and developmental biology · 2020Article
- Proteomic Analysis of Longitudinal Changes in Blood Pressure.Journal of clinical medicine · 2019Article
- The effect of body mass index and its interaction with family history on hypertension: a case-control study.Clinical hypertension · 2019Article
- Association of Mbo I-RFLP at the Renin Locus (rs2368564) with Essential Hypertension.Indian journal of clinical biochemistry : IJCB · 2016Article
- High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass.Physiological genomics · 2016Article
- STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort.Medicine · 2016Observational
- Elevated BP after AKI.Journal of the American Society of Nephrology : JASN · 2016Article
- Aggregate blood pressure responses to serial dietary sodium and potassium intervention: defining responses using independent component analysis.BMC genetics · 2015Article
- Evidence for a link between gut microbiota and hypertension in the Dahl rat.Physiological genomics · 2015Article
- Elevated blood pressure: Our family's fault? The genetics of essential hypertension.World journal of cardiology · 2014Article
- Genetics of hypertension: discoveries from the bench to human populations.American journal of physiology. Renal physiology · 2014Article
- Effects of hypertension and exercise on cardiac proteome remodelling.BioMed research international · 2014Review
- Proteomics in hypertension.Journal of human hypertension · 2013Review
- The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation.Retrovirology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Essential hypertension affects 20 to 30% of the population worldwide and contributes significantly to cardiovascular mortality and morbidity. Heridability of blood pressure is around 15 to 40% but there are also substantial environmental factors affecting blood pressure variability. It is assumed that blood pressure is under the control of a large number of genes each of which has only relatively mild effects. It has therefore been difficult to discover the genes that contribute to blood pressure variation using traditional approaches including candidate gene studies and linkage studies. Animal models of hypertension, particularly in the rat, have led to the discovery of quantitative trait loci harbouring one or several hypertension related genes, but translation of these findings into human essential hypertension remains challenging. Recent development of genotyping technology made large scale genome-wide association studies possible. This approach and the study of monogenic forms of hypertension has led to the discovery of novel and robust candidate genes for human essential hypertension, many of which require functional analysis in experimental models.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.