Evidence map›Paper›PMID 20035596›Full record

ArticleJournal of child and adolescent psychopharmacology2009

Childhood onset diagnoses in a case series of teens at clinical high risk for psychosis.

Paola Mazzoni, David Kimhy, Shamir Khan, Kelly Posner, Lawrence Maayan, Mara Eilenberg, Julie Messinger, Clarice Kestenbaum, Cheryl Corcoran

Abstract readCase Reports
In one paragraph

Article in Journal of child and adolescent psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paola MazzoniCenter of Prevention and Evaluation, New York State Psychiatric Institute at Columbia University, New York, New York 10032, USA.
David Kimhy
Shamir Khan
Kelly Posner
Lawrence Maayan
Mara Eilenberg
Julie Messinger
Clarice Kestenbaum
Cheryl Corcoran
Nathan Kline Institute for Psychiatric Research · US

Funding

Schizophrenia risk to onset: Neurobiology and preventionK23MH066279 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CORCORAN, CHERYL MARY · 2004 to 2008
$884k
NIMH NIH HHS K23 MH066279
6 · The paper itself

Abstract

reasonsSchizophrenia is typically an adult neurodevelopmental disorder that has its antecedents in childhood and adolescence. Little is known about disorders "usually first diagnosed in infancy, childhood and adolescence" (e.g., childhood-onset disorders) in "prodromal" teens at heightened clinical risk for psychotic disorder. MAIN

findingsChildhood-onset disorders were prevalent in putatively prodromal teens, including anxiety and disruptive disorders, attention-deficit/hyperactivity disorder (ADHD), and, surprisingly, elimination disorders. These may reflect developmental antecedents in psychotic disorders such as schizophrenia. KEY DATA AND STATISTICS: A case series of 9 teens (ages 13-17) identified as prodromal to psychosis were evaluated with the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). Childhood-onset diagnoses commonly endorsed (threshold or subthreshold) included ADHD (5/9), oppositional defiant disorder (5/9), enuresis or encopresis (4/9), conduct disorder (2/9), separation anxiety (3/9), and transient tic disorder (2/9). Enuresis was identified in 3 of the 4 older teens (ages 15-17). MAJOR

conclusionsAn understanding of the childhood-onset disorders that occur in teens at risk for psychotic illnesses, such as schizophrenia, can shed light on the pathophysiology of schizophrenia and potentially inform early identification and intervention.

Indexed as

Age of OnsetAdolescentAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityConduct DisorderElimination DisordersEnuresisFemaleHumansMalePsychotic DisordersRisk FactorsTic Disorders

Identifiers

PMID20035596
PMCPMC2830215
OpenAlexW2169322744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.