ReviewMolecular and cellular biochemistry2010
Role of nutritional zinc in the prevention of osteoporosis.
Review in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 1 synthesis or guideline pooled it, 394 citations in OpenAlex.
- Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.Biological trace element research · 2021Pooled it
- Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis.Clinical and experimental nephrology · 2020Trial
- Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.The Journal of nutrition · 2015Trial
- Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.The American journal of clinical nutrition · 2013Trial
- Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration.Bioactive materials · 2026Review
- Changes in Bone Parameters and Serum Zinc Levels Following Oral Zinc Supplementation in Duchenne Muscular Dystrophy: A Quasi-Experimental Study.International journal of environmental research and public health · 2026Article
- From Corrosion Control to Cell Adhesion: Parascholzite as a Functional Interface for Biodegradable Zinc Alloys.Materials (Basel, Switzerland) · 2026Article
- Article
- The Role of GPR39 in Regulating Osteoblast Function, Bone Matrix Quality, and Gender-Specific Bone Homeostasis.Journal of cellular physiology · 2025Article
- Metallomic characterization of induced periapical lesions-In vivo study.International endodontic journal · 2025Article
- Effects of dietary supplementation of organic and inorganic zinc on the performance characteristics, tissue mineralization, apparent mineral retention, and antioxidant status of broiler chicks.BMC veterinary research · 2025Article
- Preparation of Organic-Inorganic Hybrid (Sr, Ca)COACS applied bio materials · 2025Article
- Facial Proportions in Stunted and Non-Stunted Children Aged 7-72 Months: A Cross-Sectional Study in Bandung, Indonesia.Children (Basel, Switzerland) · 2025Article
- Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals.Bioactive materials · 2025Article
- Degradable calcium phosphate-coated porous zinc scaffold combined with platelet-rich plasma implantation for rabbit radius defect.European journal of medical research · 2025Article
- Trace Element Concentrations in Degenerative Lumbar Spine Tissues: Insights into Oxidative Stress.Antioxidants (Basel, Switzerland) · 2025Article
- Association between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals: a cross-sectional study.Irish journal of medical science · 2025Article
- Zinc Ameliorates High Pi and Ca-Mediated Osteogenic Differentiation of Mesenchymal Stem Cells.Nutrients · 2024Article
- Fabrication and performance of Zinc-based biodegradable metals: From conventional processes to laser powder bed fusion.Bioactive materials · 2024Review
- The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.BMC musculoskeletal disorders · 2024Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is known as an essential nutritional factor in the growth of the human and animals. Bone growth retardation is a common finding in various conditions associated with dietary zinc deficiency. Bone zinc content has been shown to decrease in aging, skeletal unloading, and postmenopausal conditions, suggesting its role in bone disorder. Zinc has been demonstrated to have a stimulatory effect on osteoblastic bone formation and mineralization; the metal directly activates aminoacyl-tRNA synthetase, a rate-limiting enzyme at translational process of protein synthesis, in the cells, and it stimulates cellular protein synthesis. Zinc has been shown to stimulate gene expression of the transcription factors runt-related transcription factor 2 (Runx2) that is related to differentiation into osteoblastic cells. Moreover, zinc has been shown to inhibit osteoclastic bone resorption due to inhibiting osteoclast-like cell formation from bone marrow cells and stimulating apoptotic cell death of mature osteoclasts. Zinc has a suppressive effect on the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL)-induced osteoclastogenesis. Zinc transporter has been shown to express in osteoblastic and osteoclastic cells. Zinc protein is involved in transcription. The intake of dietary zinc causes an increase in bone mass. beta-Alanyl-L: -histidinato zinc (AHZ) is a zinc compound, in which zinc is chelated to beta-alanyl-L: -histidine. The stimulatory effect of AHZ on bone formation is more intensive than that of zinc sulfate. Zinc acexamate has also been shown to have a potent-anabolic effect on bone. The oral administration of AHZ or zinc acexamate has the restorative effect on bone loss under various pathophysiologic conditions including aging, skeletal unloading, aluminum bone toxicity, calcium- and vitamin D-deficiency, adjuvant arthritis, estrogen deficiency, diabetes, and fracture healing. Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.