Trial reportEuropean journal of nutrition2010
A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change.
Trial report in European journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Intake of Nuts or Nut Products Does Not Lead to Weight Gain, Independent of Dietary Substitution Instructions: A Systematic Review and Meta-Analysis of Randomized Trials.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- [Olive Oil and Body Weight. Systematic Review and Meta-Analysis of Randomized Controlled Trials].Revista espanola de salud publica · 2018Pooled it
- Revisiting the Immunometabolic Basis for the Metabolic Syndrome from an Immunonutritional View.Biomedicines · 2024Review
- FTO and Anthropometrics: The Role of Modifiable Factors.Journal of functional morphology and kinesiology · 2022Review
- Gene-Environment Interactions on Body Fat Distribution.International journal of molecular sciences · 2019Review
- The Genome Landscape of Tibetan Sheep Reveals Adaptive Introgression from Argali and the History of Early Human Settlements on the Qinghai-Tibetan Plateau.Molecular biology and evolution · 2019Article
- Can a Mediterranean Diet Pattern Slow Aging?The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Dynamics of diabetes and obesity: Epidemiological perspective.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Association Between Low Dairy Intake During Pregnancy and Risk of Small-for-Gestational-Age Infants.Maternal and child health journal · 2016Article
- Specific dietary patterns and concentrations of adiponectin.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Factors associated with a low adherence to a Mediterranean diet pattern in healthy Spanish women before pregnancy.Public health nutrition · 2014Article
- Plant Oils and Cardiometabolic Risk Factors: The Role of Genetics.Current nutrition reports · 2012Article
- Fatty acid-gene interactions, adipokines and obesity.European journal of clinical nutrition · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G, and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients. SUBJECTS AND
methodsA total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G, and +276 G/T polymorphisms was done.
resultsGG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B = 1.399; B = 0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction = 0.053).
conclusionAdiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.