ArticleNeurobiology of disease2010
Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: signature of altered neural development?
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Contracted functional connectivity profiles in autism.Molecular autism · 2024Article
- Segmentation of supragranular and infragranular layers in ultra-high-resolution 7T ex vivo MRI of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Segmentation of supragranular and infragranular layers in ultra-high resolution 7TbioRxiv : the preprint server for biology · 2023Article
- Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases.Life (Basel, Switzerland) · 2023Review
- Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity.Molecular psychiatry · 2021Article
- Disturbance of phylogenetic layer-specific adaptation of human brain gene expression in Alzheimer's disease.Scientific reports · 2021Article
- Molecular signature of extracellular matrix pathology in schizophrenia.The European journal of neuroscience · 2021Article
- Neuroimaging genetic associations betweenJournal of clinical and experimental neuropsychology · 2021Article
- Semaphorins in Adult Nervous System Plasticity and Disease.Frontiers in synaptic neuroscience · 2021Review
- Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia.Science advances · 2019Article
- The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function.Nature reviews. Neuroscience · 2019Review
- Laser capture microdissection-targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia.Nature communications · 2018Article
- Genetics and Genomics of Social Behavior in a Chicken Model.Genetics · 2018Article
- Microvascular anomaly conditions in psychiatric disease. Schizophrenia - angiogenesis connection.Neuroscience and biobehavioral reviews · 2017Review
- Transcriptome sequencing of the choroid plexus in schizophrenia.Translational psychiatry · 2016Article
- In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders.Neural plasticity · 2016Review
- Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder.Molecular psychiatry · 2015Article
- Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.Biological psychiatry · 2015Article
- Schizophrenia as a disorder of molecular pathways.Biological psychiatry · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The development of the human neocortex gives rise to a complex cytoarchitecture, grouping together cells with similar structure, connectivity and function. As a result, the six neocortical laminae show distinct molecular content. In schizophrenia, many anatomical and neurochemical changes appear to be restricted to a subset of lamina and/or cell types. In this study, we hypothesized that supragranular (SG; laminae II-III) and infragranular layers (IG; laminae V-VI) of area 46 in the human prefrontal cortex will show distinct and specific transcriptome alterations between subjects with schizophrenia and matched controls. To enhance sample homogeneity, we compared the gene expression patterns of the SG and IG layers of 8 matched middle-aged male subjects with schizophrenia to 8 pairwise matched controls using two replicate DNA microarrays for each sample. The study revealed strong disease-related laminar expression differences between the SG and IG layers. Expression changes were dominated by an overall underexpression of the IG-enriched genes in the schizophrenia subjects compared to normal control subjects. Furthermore, using a diagnosis-blind, unsupervised clustering of the control-derived SG or IG-enriched transcripts, the IG-enriched markers segregated the subjects with schizophrenia from the matched controls with a high degree of confidence. Importantly, multiple members of the semaphorin gene family reported altered gene expression, suggesting that the IG gene expression disturbances in subjects with schizophrenia may be a result of altered cortical development and disrupted brain connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.