ArticleBMC genomics2009
Large-scale identification of odorant-binding proteins and chemosensory proteins from expressed sequence tags in insects.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed, 213 citations in OpenAlex.
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- Structural characterization of representative odorant receptors in Rhynchophorus ferrugineus through high-throughput modelling and extended molecular dynamics simulations.Journal of computer-aided molecular design · 2026Article
- Transcriptomic Analysis and Comparative Analysis of Gene Families Related to Environmental Adaptation in Two Grylloblattodea Species:Ecology and evolution · 2025Article
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- Comparative transcriptome analysis of the antenna and proboscis reveals feeding state-dependent chemosensory genes inOpen biology · 2024Article
- In Vivo Bioassay of the Repellent Activity of Caraway Essential Oil against Green Peach Aphid.Insects · 2023Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- iOBPdb A Database for Experimentally Determined Functional Characterization of Insect Odorant Binding Proteins.Scientific data · 2023Article
- Genome-wide identification and characterization of the chemosensory relative protein genes in Rhus gall aphid Schlechtendalia chinensis.BMC genomics · 2023Article
- Odorant-Binding Proteins and Chemosensory Proteins inInternational journal of molecular sciences · 2023Article
- Identification and sex-specific expression of chemosensory genes in the antennal transcriptomes of Pachyrhinus yasumatsui (Coleoptera: Curculionidae).Journal of insect science (Online) · 2023Article
- Odorant-Binding and Chemosensory Proteins inInternational journal of molecular sciences · 2023Article
- The Sequence Characteristics and Binding Properties of the Odorant-Binding Protein 2 ofInternational journal of molecular sciences · 2023Article
- Identification and Expression Analysis of Odorant-Binding and Chemosensory Protein Genes in Virus VectorInsects · 2022Article
- Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly,International journal of molecular sciences · 2022Article
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- Analysis of the Antennal Transcriptome and Identification of Tissue-specific Expression of Olfactory-related Genes in Micromelalopha troglodyta (Lepidoptera: Notodontidae).Journal of insect science (Online) · 2022Article
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- Evolutionarily conserved odorant-binding proteins participate in establishing tritrophic interactions.iScience · 2022Article
- The Antennal Sensilla and Expression Patterns of Olfactory Genes in the Lower Termite Reticulitermes aculabialis (Isoptera: Rhinotermitidae).Journal of insect science (Online) · 2022Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsect odorant binding proteins (OBPs) and chemosensory proteins (CSPs) play an important role in chemical communication of insects. Gene discovery of these proteins is a time-consuming task. In recent years, expressed sequence tags (ESTs) of many insect species have accumulated, thus providing a useful resource for gene discovery.
resultsWe have developed a computational pipeline to identify OBP and CSP genes from insect ESTs. In total, 752,841 insect ESTs were examined from 54 species covering eight Orders of Insecta. From these ESTs, 142 OBPs and 177 CSPs were identified, of which 117 OBPs and 129 CSPs are new. The complete open reading frames (ORFs) of 88 OBPs and 123 CSPs were obtained by electronic elongation. We randomly chose 26 OBPs from eight species of insects, and 21 CSPs from four species for RT-PCR validation. Twenty two OBPs and 16 CSPs were confirmed by RT-PCR, proving the efficiency and reliability of the algorithm. Together with all family members obtained from the NCBI (OBPs) or the UniProtKB (CSPs), 850 OBPs and 237 CSPs were analyzed for their structural characteristics and evolutionary relationship.
conclusionsA large number of new OBPs and CSPs were found, providing the basis for deeper understanding of these proteins. In addition, the conserved motif and evolutionary analysis provide some new insights into the evolution of insect OBPs and CSPs. Motif pattern fine-tune the functions of OBPs and CSPs, leading to the minor difference in binding sex pheromone or plant volatiles in different insect Orders.
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