ArticleThe Journal of comparative neurology2010
Altered balance of gamma-aminobutyric acidergic and glutamatergic afferent inputs in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus of renovascular hypertensive rats.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Neural Progenitor Cells and the Hypothalamus.Cells · 2023Review
- Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review.Current neuropharmacology · 2020Review
- Renal Sensory Activity Regulates the γ-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension.Frontiers in physiology · 2020Article
- Exercise training augments neuronal nitric oxide synthase dimerization in the paraventricular nucleus of rats with chronic heart failure.Nitric oxide : biology and chemistry · 2019Article
- Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat.The Journal of comparative neurology · 2019Article
- Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension.Neuroscience bulletin · 2019Review
- Chronic Intracerebroventricular Infusion of Metformin Inhibits Salt-Sensitive Hypertension via Attenuation of Oxidative Stress and Neurohormonal Excitation in Rat Paraventricular Nucleus.Neuroscience bulletin · 2019Article
- Angiotensin-(1-7) attenuates hypertension and cardiac hypertrophyRSC advances · 2018Article
- Expression of Proinflammatory Cytokines Is Upregulated in the Hypothalamic Paraventricular Nucleus of Dahl Salt-Sensitive Hypertensive Rats.Frontiers in physiology · 2018Article
- Altered NMDA receptor-evoked intracellular CaThe Journal of physiology · 2017Article
- Sedentary conditions and enhanced responses to GABA in the RVLM: role of the contralateral RVLM.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- An increased extrasynaptic NMDA tone inhibits A-type KThe Journal of physiology · 2017Article
- Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation.Physiological reports · 2017Article
- Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control.Molecular metabolism · 2016Article
- Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.American journal of physiology. Heart and circulatory physiology · 2016Article
- Paradoxical Sleep Deprivation Causes Cardiac Dysfunction and the Impairment Is Attenuated by Resistance Training.PloS one · 2016Article
- Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.Endocrinology · 2015Article
- Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation.The Journal of physiology · 2014Article
- Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier.Hypertension (Dallas, Tex. : 1979) · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
An imbalance of excitatory and inhibitory functions has been shown to contribute to numerous pathological disorders. Accumulating evidence supports the idea that a change in hypothalamic gamma-aminobutyric acid (GABA)-ergic inhibitory and glutamatergic excitatory synaptic functions contributes to exacerbated neurohumoral drive in prevalent cardiovascular disorders, including hypertension. However, the precise underlying mechanisms and neuronal substrates are still not fully elucidated. In the present study, we combined quantitative immunohistochemistry with neuronal tract tracing to determine whether plastic remodeling of afferent GABAergic and glutamatergic inputs into identified RVLM-projecting neurons of the hypothalamic paraventricular nucleus (PVN-RVLM) contributes to an imbalanced excitatory/inhibitory function in renovascular hypertensive rats (RVH). Our results indicate that both GABAergic and glutamatergic innervation densities increased in oxytocin-positive, PVN-RVLM (OT-PVN-RVLM) neurons in RVH rats. Despite this concomitant increase, time-dependent and compartment-specific differences in the reorganization of these inputs resulted in an altered balance of excitatory/inhibitory inputs in somatic and dendritic compartments. A net predominance of excitatory over inhibitory inputs was found in OT-PVN-RVLM proximal dendrites. Our results indicate that, along with previously described changes in neurotransmitter release probability and postsynaptic receptor function, remodeling of GABAergic and glutamatergic afferent inputs contributes as an underlying mechanism to the altered excitatory/inhibitory balance in the PVN of hypertensive rats.
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