ArticleBehavior genetics2010
Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains.
Article in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Brief introduction in phenotypic and genetic differences of C57BL/6 and BALB/c mice substrains.Animal models and experimental medicine · 2025Review
- Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3BNature communications · 2025Article
- Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.The Journal of pharmacology and experimental therapeutics · 2022Article
- Deviant circadian rhythmicity, corticosterone variability and trait testosterone levels in aggressive mice.The European journal of neuroscience · 2022Article
- Environmental Enrichment Differentially Activates Neural Circuits in FVB/N Mice, Inducing Social Interaction in Females but Agonistic Behavior in Males.Neurochemical research · 2022Article
- Assessment of Binge-Like Eating of Unsweetened vs. Sweetened Chow Pellets in BALB/c Substrains.Frontiers in behavioral neuroscience · 2022Article
- Comparison of cisplatin-induced anti-tumor response in CT26 syngeneic tumors of three BALB/c substrains.Laboratory animal research · 2021Article
- A Common Space Approach to Comparative Neuroscience.Annual review of neuroscience · 2021Article
- Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice.Brain sciences · 2021Article
- Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice.Infection and immunity · 2020Article
- Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment.Laboratory animal research · 2020Article
- Methylphenidate administration promotes sociability and reduces aggression in a mouse model of callousness.Psychopharmacology · 2019Article
- Aggression in BALB/cJ mice is differentially predicted by the volumes of anterior and midcingulate cortex.Brain structure & function · 2019Article
- The Virtual-Environment-Foraging Task enables rapid training and single-trial metrics of rule acquisition and reversal in head-fixed mice.Scientific reports · 2019Article
- Methylphenidate Dose-Dependently Affects Aggression and Improves Fear Extinction and Anxiety in BALB/cJ Mice.Frontiers in psychiatry · 2019Article
- Gradient of Parvalbumin- and Somatostatin-Expressing Interneurons Across Cingulate Cortex Is Differentially Linked to Aggression and Sociability in BALB/cJ Mice.Frontiers in psychiatry · 2019Article
- Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice.Scientific reports · 2018Article
- Article
- Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Some BALB/c substrains exhibit different levels of aggression. We compared aggression levels between male BALB/cJ and BALB/cByJ substrains using the resident intruder paradigm. These substrains were also assessed in other tests of emotionality and information processing including the open field, forced swim, fear conditioning, and prepulse inhibition tests. We also evaluated single nucleotide polymorphisms (SNPs) previously reported between these BALB/c substrains. Finally, we compared BALB/cJ and BALB/cByJ mice for genomic deletions or duplications, collectively termed copy number variants (CNVs), to identify candidate genes that might underlie the observed behavioral differences. BALB/cJ mice showed substantially higher aggression levels than BALB/cByJ mice; however, only minor differences in other behaviors were observed. None of the previously reported SNPs were verified. Eleven CNV regions were identified between the two BALB/c substrains. Our findings identify a robust difference in aggressive behavior between BALB/cJ and BALB/cByJ substrains, which could be the result of the identified CNVs.
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