ReviewEuropean child & adolescent psychiatry2010
Eating disorders: the current status of molecular genetic research.
Review in European child & adolescent psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders.Journal of psychiatric research · 2017Pooled it
- Neural circuit control of innate behaviors.Science China. Life sciences · 2022Review
- Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders.Frontiers in pharmacology · 2022Article
- Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm.The Journal of pharmacology and experimental therapeutics · 2019Article
- Sex Differences in Adolescent Anorexia and Bulimia Nervosa: Beyond the Signs and Symptoms.Current psychiatry reports · 2019Review
- Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study.Psychological medicine · 2015Article
- The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.Frontiers in endocrinology · 2015Review
- Preliminary evidence for the role of HTR2A variants in binge eating in young women.Psychiatric genetics · 2014Article
- Genetics of eating disorders.Current psychiatry reports · 2013Review
- Is deep brain stimulation a treatment option for anorexia nervosa?BMC psychiatry · 2013Review
- Genetic variants associated with disordered eating.The International journal of eating disorders · 2013Article
- Ghrelin and eating disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology.Social science & medicine (1982) · 2012Review
- A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study.Nutrition & metabolism · 2011Article
- Genetics and Epigenetics of Eating Disorders.Psychiatric annals · 2011Article
- Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.Nature · 2011Article
- Prevalence and correlates of eating disorders in adolescents. Results from the national comorbidity survey replication adolescent supplement.Archives of general psychiatry · 2011Article
- Child and adolescent psychiatric genetics.European child & adolescent psychiatry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders characterized by disordered eating behavior where the patient's attitude towards weight and shape, as well as their perception of body shape, are disturbed. Formal genetic studies on twins and families suggested a substantial genetic influence for AN and BN. Candidate gene studies have initially focused on the serotonergic and other central neurotransmitter systems and on genes involved in body weight regulation. Hardly any of the positive findings achieved in these studies were unequivocally confirmed or substantiated in meta-analyses. This might be due to too small sample sizes and thus low power and/or the genes underlying eating disorders have not yet been analyzed. However, some studies that also used subphenotypes (e.g., restricting type of AN) led to more specific results; however, confirmation is as yet mostly lacking. Systematic genome-wide linkage scans based on families with at least two individuals with an eating disorder (AN or BN) revealed initial linkage regions on chromosomes 1, 3 and 4 (AN) and 10p (BN). Analyses on candidate genes in the chromosome 1 linkage region led to the (as yet unconfirmed) identification of certain variants associated with AN. Genome-wide association studies are under way and will presumably help to identify genes and pathways involved in these eating disorders. The elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.