ArticleMammalian genome : official journal of the International Mammalian Genome Society2010
A method for mapping intralocus interactions influencing excessive alcohol drinking.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.Brain sciences · 2026Article
- Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025Review
- Discovery and validation of genes driving drug-intake and related behavioral traits in mice.Genes, brain, and behavior · 2024Article
- Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity.Alcohol, clinical & experimental research · 2023Article
- DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE.bioRxiv : the preprint server for biology · 2023Article
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals.Frontiers in neuroscience · 2019Article
- No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol-related behaviors.BMC research notes · 2017Article
- Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication.Behavioural brain research · 2016Article
- Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication.Genes, brain, and behavior · 2015Article
- High drinking in the dark mice: a genetic model of drinking to intoxication.Alcohol (Fayetteville, N.Y.) · 2014Review
- "Drinking in the dark" (DID) procedures: a model of binge-like ethanol drinking in non-dependent mice.Alcohol (Fayetteville, N.Y.) · 2014Review
- Oral Nicotine Self-Administration in Rodents.Journal of addiction research & therapy · 2012Article
- Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models.Alcohol research : current reviews · 2012Article
- Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark.Alcohol (Fayetteville, N.Y.) · 2011Article
- A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.Neuropharmacology · 2011Article
- The μ opioid receptor is not involved in ethanol-stimulated dopamine release in the ventral striatum of C57BL/6J mice.Alcoholism, clinical and experimental research · 2011Article
- Preclinical studies of alcohol binge drinking.Annals of the New York Academy of Sciences · 2011Review
- The complexity of alcohol drinking: studies in rodent genetic models.Behavior genetics · 2010Review
- Epigenetics and biomarkers in the staging of neuropsychiatric disorders.Neurotoxicity research · 2010Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Excessive alcohol (ethanol) consumption is the hallmark of alcohol use disorders. The F1 hybrid cross between the C57BL/6J (B6) and FVB/NJ (FVB) inbred mouse strains consumes more ethanol than either progenitor strain. The purpose of this study was to utilize ethanol-drinking data and genetic information to map genes that result in overdominant (or heterotic) ethanol drinking. About 600 B6 x FVB F2 mice, half of each sex, were tested for ethanol intake and preference in a 24-h, two-bottle water versus ethanol choice procedure, with ascending ethanol concentrations. They were then tested for ethanol intake in a Drinking in the Dark (DID) procedure, first when there was no water choice and then when ethanol was offered versus water. DNA samples were obtained and genome-wide QTL analyses were performed to search for single QTLs (both additive and dominance effects) and interactions between pairs of QTLs, or epistasis. On average, F2 mice consumed excessive amounts of ethanol in the 24-h choice procedure, consistent with high levels of consumption seen in the F1 cross. Consumption in the DID procedure was similar or higher than amounts reported previously for the B6 progenitor. QTLs resulting in heightened consumption in heterozygous compared to homozygous animals were found on Chrs 11, 15, and 16 for 24-h choice 30% ethanol consumption, and on Chr 11 for DID. No evidence was found for epistasis between any pair of significant or suggestive QTLs. This indicates that the hybrid overdominance is due to intralocus interactions at the level of individual QTL.
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