ReviewPediatric cardiology2010
Genetic origins of pediatric heart disease.
Review in Pediatric cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of NKX2-5 Genetic Polymorphisms with the Risk of Congenital Heart Disease: A Meta-analysis.Pediatric cardiology · 2016Pooled it
- Associations between two genetic variants in NKX2-5 and risk of congenital heart disease in Chinese population: a meta-analysis.PloS one · 2013Pooled it
- The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024Review
- Cardiac Transcription Factors and Regulatory Networks.Advances in experimental medicine and biology · 2024Review
- Genetic Alterations of Transcription Factors and Signaling Molecules Involved in the Development of Congenital Heart Defects-A Narrative Review.Children (Basel, Switzerland) · 2023Review
- Article
- A young boy with ventricular arrhythmias and thyroid dysgenesis: two genes are not enough?Archives of endocrinology and metabolism · 2023Article
- Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part.Scientific reports · 2021Article
- Article
- Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies.Frontiers in cardiovascular medicine · 2018Article
- Point mutations in murineJCI insight · 2017Article
- A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects.Annals of human genetics · 2016Article
- NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity.Scientific reports · 2015Article
- Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia.Hypertension in pregnancy · 2014Article
- Novel and highly lethal NKX2.5 missense mutation in a family with sudden death and ventricular arrhythmia.Pediatric cardiology · 2014Article
- A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation.Circulation. Cardiovascular genetics · 2014Article
- GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect.Pediatric cardiology · 2013Article
- Evolutionary conservation of Nkx2.5 autoregulation in the second heart field.Developmental biology · 2013Article
- Novel GATA6 mutations associated with congenital ventricular septal defect or tetralogy of fallot.DNA and cell biology · 2012Article
- Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation.Circulation. Cardiovascular genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Pediatric heart disease comprises many forms of cardiovascular disease in the young including cardiovascular malformations (CVM), cardiomyopathies, vasculopathies, e.g., Marfan syndrome, and cardiac arrhythmias. CVM are an important component of pediatric heart disease and constitute a major portion of clinically significant birth defects. In the past decade, the complementary nature of genetic, developmental, and biochemical approaches have contributed to extraordinary advances in understanding the origins of pediatric heart disease. Results of the studies of the cardiac transcription factor, NKX2.5, illustrate these accomplishments and at the same time provide a forecast of the nature of future genetic studies to better understand the origins of pediatric heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.