ReviewPediatric cardiology2010
Hey bHLH factors in cardiovascular development.
Review in Pediatric cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Epigenetic Evaluation of theCells · 2023Article
- Article
- Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice.Journal of cell communication and signaling · 2022Article
- Constructing a new prognostic signature of gastric cancer based on multiple data sets.Bioengineered · 2021Article
- Notch signaling-modified mesenchymal stem cells improve tissue perfusion by induction of arteriogenesis in a rat hindlimb ischemia model.Scientific reports · 2021Article
- Adding a "Notch" to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach.Frontiers in cell and developmental biology · 2021Review
- Melatonin as a protective agent in cardiac ischemia-reperfusion injury: Vision/Illusion?European journal of pharmacology · 2020Review
- Endothelial to Mesenchymal Transition in the Cardiogenesis and Cardiovascular Diseases.Current cardiology reviews · 2020Review
- Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury.Molecular medicine reports · 2018Article
- Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.PloS one · 2015Article
- Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.PloS one · 2015Article
- The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms.Clinical & experimental metastasis · 2014Review
- The role of Notch pathway in cardiovascular diseases.Global cardiology science & practice · 2013Review
- HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway.Biology open · 2012Article
- Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.PLoS genetics · 2012Article
- Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events.PloS one · 2012Article
- Expression of HES and HEY genes in infantile hemangiomas.Vascular cell · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Notch pathway is now firmly established as a key signaling system for embryonic cardiovascular development as well as some adult pathologies in vertebrates. We have identified Hey bHLH transcriptional repressors as critical, but partly redundant transducers of these signals. Hey proteins control cardiomyocyte differentiation, epithelial to mesenchymal transition of endocardial cells, and a number of key features of arterial endothelial cells with corresponding defects in knockout mice. While most of the phenotypes are described in embryonic development, there is increasing evidence for additional adult pathologies. Despite the functional importance of Hey proteins little is still known about their molecular targets and interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.