ReviewMucosal immunology2010
New insights into innate immune mechanisms underlying allergenicity.
Review in Mucosal immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 127 citations in OpenAlex.
- Group 2 innate lymphoid cells program pulmonary adaptive immunity via granulocyte-macrophage colony-stimulating factor.The Journal of allergy and clinical immunology · 2026Article
- Modulation of oral vaccine efficacy by the gut microbiota.NPJ vaccines · 2025Review
- From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.Frontiers in allergy · 2025Review
- Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring.Tissue engineering and regenerative medicine · 2024Review
- Interleukins: pathophysiological role in acute pancreatitis.Archives of medical science : AMS · 2024Article
- Diagnostic and Prognostic Value of IL-10, FABP2 and LPS Levels in HCC Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Going over Fungal Allergy:Journal of fungi (Basel, Switzerland) · 2023Review
- Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy.Journal of public health in Africa · 2023Article
- Chitinase Signature in the Plasticity of Neurodegenerative Diseases.International journal of molecular sciences · 2023Review
- Dual Role of Chitin as the Double Edged Sword in Controlling the NLRP3 Inflammasome Driven Gastrointestinal and Gynaecological Tumours.Marine drugs · 2022Review
- Editorial: Activation of Innate Immunity by Allergens and Allergenic Sources.Frontiers in allergy · 2021Article
- Article
- Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.Nature immunology · 2020Article
- The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis.Advances in wound care · 2020Review
- Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components.Pulmonary medicine · 2020Article
- New insights into roles of basophils in initiating T helper type 2 immunity.Chinese herbal medicines · 2020Article
- The Role of Dust Mites in Allergy.Clinical reviews in allergy & immunology · 2019Review
- Innate and adaptive immune responses to fungi in the airway.The Journal of allergy and clinical immunology · 2018Review
- House dust mite induced allergic airway disease is attenuated in CD11cScientific reports · 2018Article
- Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.The Journal of allergy and clinical immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that the ability of such proteins to promote allergic responses in susceptible hosts is a function of their ability to interact with diverse pathways of innate immune recognition and activation at mucosal surfaces. This review highlights recent insights into innate immune activation by allergens--through proteolytic activity, engagement of pattern recognition receptors, molecular mimicry of TLR signaling complex molecules, lipid-binding activity, and oxidant potential--and the role of such activation in inducing allergic disease. A greater understanding of the fundamental origins of allergenicity should help define new preventive and therapeutic targets in allergic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.