ArticleAmerican journal of physiology. Renal physiology2010
Angiotensin II AT2 receptor regulates ureteric bud morphogenesis.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
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- Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development.Nature communications · 2025Article
- The Angiotensin ATPharmacological reviews · 2022Review
- Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- The origin and role of the renal stroma.Development (Cambridge, England) · 2021Review
- ATDiabetologia · 2021Article
- Maternal protein restriction induces renal AT2R promoter hypomethylation in salt-sensitive, hypertensive rats.Food science & nutrition · 2021Article
- Renin-angiotensin system in mammalian kidney development.Pediatric nephrology (Berlin, Germany) · 2021Review
- Association of vesicoureteral reflux and gastroesophageal reflux disease in children: A population-based study.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development.Pediatric research · 2017Article
- Developmental Genetics and Congenital Anomalies of the Kidney and Urinary Tract.Journal of pediatric genetics · 2016Review
- Vascular versus tubular renin: role in kidney development.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning.Molecular reproduction and development · 2015Review
- AT2 receptor activities and pathophysiological implications.Journal of cardiovascular pharmacology · 2015Review
- Renin-angiotensin system in ureteric bud branching morphogenesis: implications for kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Article
- Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats.Pediatric nephrology (Berlin, Germany) · 2011Article
- Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms.Pediatric nephrology (Berlin, Germany) · 2011Review
- Genetics of vesicoureteral reflux.Nature reviews. Urology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
ANG II AT2 receptor (AT2R)-deficient mice exhibit abnormal ureteric bud (UB) budding, increased incidence of double ureters, and vesicoureteral reflux. However, the role of the AT2R during UB morphogenesis and the mechanisms by which aberrant AT2R signaling disrupts renal collecting system development have not been fully defined. In this study, we mapped the expression of the AT2R during mouse metanephric development, examined the impact of disrupted AT2R signaling on UB branching, cell proliferation, and survival, and investigated the cross talk of the AT2R with the glial-derived neurotrophic factor (GDNF)/c-Ret/Wnt11 signaling pathway. Embryonic mouse kidneys express AT2R in the branching UB and the mesenchyme. Treatment of embryonic day 12.5 (E12.5) metanephroi with the AT2R antagonist PD123319 or genetic inactivation of the AT2R in mice inhibits UB branching, decreasing the number of UB tips compared with control (34 +/- 1.0 vs. 43 +/- 0.6, P < 0.01; 36 +/- 1.8 vs. 48 +/- 1.3, P < 0.01, respectively). In contrast, treatment of metanephroi with the AT2R agonist CGP42112 increases the number of UB tips compared with control (48 +/- 1.8 vs. 39 +/- 12.3, P < 0.05). Using real-time quantitative RT-PCR and whole mount in situ hybridization, we demonstrate that PD123319 downregulates the expression of GDNF, c-Ret, Wnt11, and Spry1 mRNA levels in E12.5 metanephroi grown ex vivo. AT(2)R blockade or genetic inactivation of AT2R stimulates apoptosis and inhibits proliferation of the UB cells in vivo. We conclude that AT2R performs essential functions during UB branching morphogenesis via control of the GDNF/c-Ret/Wnt11 signaling pathway, UB cell proliferation, and survival.
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