ArticleEndocrinology2010
Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids.Science advances · 2026Article
- IGF-mediated glucose signalling is retained in adult naked mole-rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum.NPJ Regenerative medicine · 2024Article
- Methylation alterations of imprinted genes in different placental diseases.Clinical epigenetics · 2024Article
- Hypoxia impairs blood glucose homeostasis in naked mole-rat adult subordinates but not queens.The Journal of experimental biology · 2024Article
- Activation of the insulin receptor by insulin-like growth factor 2.Nature communications · 2024Article
- Insulin-like growth factor-2 is a promising candidate for the treatment and prevention of Alzheimer's disease.CNS neuroscience & therapeutics · 2023Review
- Review
- Mid- to late-gestational maternal nutrient restriction followed by realimentation alters development and lipid composition of liver and skeletal muscles in ovine fetuses.Journal of animal science · 2021Article
- Placental Corticotrophin-Releasing Hormone is a Modulator of Fetal Liver Blood Perfusion.The Journal of clinical endocrinology and metabolism · 2021Article
- Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization.The Journal of endocrinology · 2020Article
- The maturity in fetal pigs using a multi-fluid metabolomic approach.Scientific reports · 2020Article
- Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity.American journal of obstetrics and gynecology · 2017Article
- Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.Cell reports · 2014Article
- Upregulation of IGF2 expression during vascular calcification.Journal of molecular endocrinology · 2014Article
- Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion.The Journal of biological chemistry · 2014Article
- Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.Molecular cancer therapeutics · 2012Article
- Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.The International journal of developmental biology · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Whether insulin or IGFs regulate glycogen synthesis in the fetal liver remains to be determined. In this study, we used several knockout mouse strains, including those lacking Pdx-1 (pancreatic duodenal homeobox-1), Insr (insulin receptor), and Igf2 (IGF-II) to determine the role of these genes in the regulation of fetal hepatic glycogen synthesis. Our data show that insulin deficiency does not alter hepatic glycogen stores, whereas Insr and Igf2 deficiency do. We found that both insulin receptor isoforms (IR-A and IR-B) are present in the fetal liver, and their expression is gestationally regulated. IR-B is highly expressed in the fetal liver; nonetheless, the percentage of hepatic IR-A isoform, which binds Igf2, was significantly higher in the fetus than the adult. In vitro experiments demonstrate that Igf2 increases phosphorylation of hepatic Insr, insulin receptor substrate-2, and Akt proteins and also the activity of glycogen synthase. Igf2 ultimately increased glycogen synthesis in fetal hepatocytes. This increase could be blocked by the phosphoinositide 3-kinase inhibitor LY294008. Taken together, we propose Igf2 as a major regulator of fetal hepatic glycogen metabolism, the insulin receptor as its target receptor, and phosphoinositide 3-kinase as the signaling pathway leading to glycogen formation in the fetal liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.