ArticleEndocrinology2010
Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Study on the Function ofAnimals : an open access journal from MDPI · 2025Article
- Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.Frontiers in endocrinology · 2023Article
- An integrated transcriptome and microbial community analysis reveals potential mechanisms for increased immune responses when replacing silybum marianum meal with soybean meal in growing lambs.Frontiers in microbiology · 2023Article
- Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.International journal of molecular sciences · 2021Article
- Genes regulating hormone stimulus and response to protein signaling revealed differential expression pattern during porcine oocyte in vitro maturation, confirmed by lipid concentration.Histochemistry and cell biology · 2020Article
- Milk lactoperoxidase decreases ID1 and ID3 expression in human oral squamous cell carcinoma cell lines.Scientific reports · 2020Article
- Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM - a microarray approach.Reproductive biology and endocrinology : RB&E · 2017Article
- Characterization of Inhibitor of differentiation (Id) proteins in human cornea.Experimental eye research · 2016Article
- Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides.Reproductive biology and endocrinology : RB&E · 2015Article
- BMP signaling is required for cell cleavage in preimplantation-mouse embryos.Developmental biology · 2015Article
- Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles.Biology of reproduction · 2015Article
- Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Decreased Expression of Inhibitor of DNA-binding (Id) Proteins and Vascular Endothelial Growth Factor and Increased Apoptosis in Ovarian Aging.Development & reproduction · 2013Article
- Article
- Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model.Reproductive biology and endocrinology : RB&E · 2012Article
- Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells.Molecular and cellular endocrinology · 2012Review
- TGF-β mediated DNA methylation in prostate cancer.Translational andrology and urology · 2012Article
- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.Experimental & molecular medicine · 2012Article
- Inhibin removes the inhibitory effects of activin on steroid enzyme expression and androgen production by normal ovarian thecal cells.Journal of molecular endocrinology · 2012Article
- Human cumulus cells molecular signature in relation to oocyte nuclear maturity stage.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Inhibitor of differentiation (Id) proteins act during embryogenesis and development to repress gene transcription required for lineage commitment, while promoting cell growth. Growth factors belonging to the TGFbeta superfamily of signaling molecules, notably the bone morphogenetic proteins (BMPs) and activin, can regulate Id expression in these tissues. Id expression and function in adult physiology is less well determined, and we hypothesized a role for Id proteins in the adult mammalian ovary. Immunohistochemistry for Id1, Id2, Id3, and Id4 in the sheep ovary revealed consistent expression in granulosa and thecal cells of ovarian follicles throughout development. In atretic follicles, Id proteins were selectively down-regulated in thecal cells (P < 0.0001). Additionally, Id1 was universally up-regulated in the cumulus cells adjacent to the oocyte. Immunohistochemistry for phospho (p)-smad 1/5/8 signaling components (stimulated by BMPs) showed a punctate pattern of expression whereas p-smad 2/3 (stimulated by activin) was ubiquitously expressed in follicles. Neither pathway, however, displayed differential staining in line with Id1 cumulus-specific expression, suggesting a more complex relationship between Id1 expression and TGFbeta signaling in these cells. Nevertheless, in vitro, stimulation of ovine granulosa cells with BMP6 or activin A led to a respective increase and decrease in Id1 (P < 0.0001), Id2 (P < 0.0001), Id3 (P < 0.0001), and Id4 (P < 0.05) transcripts, and Id1 gene expression was further manipulated by the oocyte-secreted factors BMP15 and growth differentiation factor 9 (P < 0.001). These data confirm that TGFbeta signaling can regulate Id gene expression in the sheep ovarian follicle and suggest a functional role for the Id family in the mammalian ovary.
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