ArticleEndocrinology2010
The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms.Acta physiologica (Oxford, England) · 2026Review
- Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking.Hormones and behavior · 2025Article
- Cushing's Syndrome Effects on the Thyroid.International journal of molecular sciences · 2021Review
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- Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis.Frontiers in endocrinology · 2019Review
- New insights into thyroid hormone action.Pharmacology & therapeutics · 2017Review
- Advances in TRH signaling.Reviews in endocrine & metabolic disorders · 2016Review
- ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance.Frontiers in cellular neuroscience · 2016Article
- Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.The Journal of clinical investigation · 2014Article
- Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.Endocrine reviews · 2014Review
- Examination of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in development and adulthood.Neuroendocrinology · 2014Article
- Thyroid Hormone Upregulates Hypothalamic kiss2 Gene in the Male Nile Tilapia, Oreochromis niloticus.Frontiers in endocrinology · 2013Article
- The thyroid axis is regulated by NCoR1 via its actions in the pituitary.Endocrinology · 2012Article
- Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis.Endocrinology · 2012Review
- Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.Endocrinology · 2012Article
- Animal models as tools to investigate antidiabetic and anti-inflammatory plants.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.Cell metabolism · 2011Article
- Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.The Journal of endocrinology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The expression of the TRH gene in the paraventricular nucleus (PVH) of the hypothalamus is required for the normal production of thyroid hormone (TH) in rodents and humans. In addition, the regulation of TRH mRNA expression by TH, specifically in the PVH, ensures tight control of the set point of the hypothalamic-pituitary-thyroid axis. Although many studies have assumed that the regulation of TRH expression by TH is at the level of transcription, there is little data available to demonstrate this. We used two in vivo model systems to show this. In the first model system, we developed an in situ hybridization (ISH) assay directed against TRH heteronuclear RNA to measure TRH transcription directly in vivo. We show that in the euthyroid state, TRH transcription is present both in the PVH and anterior/lateral hypothalamus. In the hypothyroid state, transcription is activated in the PVH only and can be shut off within 5 h by TH. In the second model system, we employed transgenic mice that express the Cre recombinase under the control of the genomic region containing the TRH gene. Remarkably, TH regulates Cre expression in these mice in the PVH only. Taken together, these data affirm that TH regulates TRH at the level of transcription in the PVH only and that genomic elements surrounding the TRH gene mediate its regulation by T(3). Thus, it should be possible to identify the elements within the TRH locus that mediate its regulation by T(3) using in vivo approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.