ArticleEndocrinology2010
The follistatin-288 isoform alone is sufficient for survival but not for normal fertility in mice.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice.Cells · 2022Article
- Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Myostatin and Follistatin-New Kids on the Block in the Diagnosis of Sarcopenia in IBD and Possible Therapeutic Implications.Biomedicines · 2021Review
- Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes.International journal of obesity (2005) · 2021Article
- A non-coding region nearProceedings. Biological sciences · 2018Article
- Follistatin is critical for mouse uterine receptivity and decidualization.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Activins and Inhibins: Roles in Development, Physiology, and Disease.Cold Spring Harbor perspectives in biology · 2016Review
- Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli.AMB Express · 2015Article
- Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.PloS one · 2015Article
- Inhibin at 90: from discovery to clinical application, a historical review.Endocrine reviews · 2014Review
- Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice.Endocrinology · 2013Article
- Regulation of the ovarian reserve by members of the transforming growth factor beta family.Molecular reproduction and development · 2012Review
- Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.American journal of physiology. Endocrinology and metabolism · 2012Article
- Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.Molecular and cellular endocrinology · 2012Review
- Follistatin and follistatin like-3 differentially regulate adiposity and glucose homeostasis.Obesity (Silver Spring, Md.) · 2011Article
- Follistatin regulates germ cell nest breakdown and primordial follicle formation.Endocrinology · 2011Article
- The Local Control of the Pituitary by Activin Signaling and Modulation.Open neuroendocrinology journal (Online) · 2011Article
- Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Follistatin (FST) is a natural antagonist of activin and related TGFbeta superfamily ligands that exists as three protein isoforms differing in length at the C terminus. The longest FST315 isoform is found in the circulation, whereas the shortest FST288 isoform is typically found in or on cells and tissues, and the intermediate FST303 isoform is found in gonads. We recently demonstrated that the FST isoforms have distinct biological actions in vitro that, taken together with the differential distribution, suggests they may also have different roles in vivo. To explore the specific role of individual FST isoforms, we created a single-isoform FST288-only mouse. In contrast to the neonatal death of FST global knockout mice, FST288-only mice survive to adulthood. Although they appear normal, FST288-only mice have fertility defects including reduced litter size and frequency. Follicles were counted in ovaries from 8.5- to 400-d-old females. Significantly fewer morphologically healthy antral follicles were found in 100- to 250-d FST288-only ovaries, but there were significantly more secondary, primary, and primordial follicles detected at d 8.5 in FST288-only ovaries. However, depletion of this primordial follicle pool is more rapid in FST288-only females resulting in a deficit by 250 d of age and early cessation of reproduction. Superovulated FST288-only females have fewer ovulated eggs and embryos. These results indicate that the FST isoforms have different activities in vivo, that the FST288-only isoform is sufficient for development, and that loss of FST303 and FST315 isoforms results in fertility defects that resemble activin hyperactivity and premature ovarian failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.