ArticleJournal of the Royal Society, Interface2010
Strontium borate glass: potential biomaterial for bone regeneration.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 161 citations in OpenAlex.
- Influence of ZnO Addition on the Structural and Biological Properties of Borate Bioactive Glasses for Bone Tissue Regeneration.ACS omega · 2026Article
- Bone void filler materials for augmentation in comminuted fractures: a comprehensive review.Journal of orthopaedic surgery and research · 2025Review
- Article
- Properties and antibacterial effectiveness of metal-ion doped borate-based bioactive glasses.Future microbiology · 2025Review
- Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations.Biomaterials research · 2025Review
- High Boron Content Enhances Bioactive Glass Biodegradation.Journal of functional biomaterials · 2023Article
- Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.Bioactive materials · 2023Article
- Effect of pH on the In Vitro Degradation of Borosilicate Bioactive Glass and Its Modulation by Direct Current Electric Field.Materials (Basel, Switzerland) · 2022Article
- Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí's Contribution.Pharmaceutics · 2022Review
- Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway.Bioactive materials · 2020Article
- Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia.Frontiers in bioengineering and biotechnology · 2020Review
- Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering.Frontiers in bioengineering and biotechnology · 2019Review
- Novel bioglasses for bone tissue repair and regeneration: Effect of glass design on sintering ability, ion release and biocompatibility.Materials & design · 2017Article
- Effect of strontium substitution on the cytocompatibility and 3-D scaffold structure for the xSrO-(10-x) MgO-60SiOJournal of materials science. Materials in medicine · 2017Article
- A comparative study of strontium-substituted hydroxyapatite coating on implant's osseointegration for osteopenic rats.Medical & biological engineering & computing · 2016Article
- Strontium coating by electrochemical deposition improves implant osseointegration in osteopenic models.Experimental and therapeutic medicine · 2015Article
- Morphology, composition, and bioactivity of strontium-doped brushite coatings deposited on titanium implants via electrochemical deposition.International journal of molecular sciences · 2014Article
- Deregulation of bone forming cells in bone diseases and anabolic effects of strontium-containing agents and biomaterials.BioMed research international · 2014Review
- Hydrothermal preparation and characterization of ultralong strontium-substituted hydroxyapatite whiskers using acetamide as homogeneous precipitation reagent.TheScientificWorldJournal · 2014Article
- Bioactive glass in tissue engineering.Acta biomaterialia · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Boron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.